PDB-code
| Kinase structure | |
| Kinase: | EPHA7 (EphA7) |
| Family: | Eph |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1827 |
| PDB: | 3DKO |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2008-08-19 |
| PubMed: | 19553108 |
| Chain: | A |
| (Alternate) Model: | A |
| Orthosteric ligand: | IHZ |
 | |
| More entries for 3DKO | |||||
| 3DKO | Alternative model: | B | Chain: | A | |
| Structural information | |
| DFG conformation: | out |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | - |
| G-rich loop rotation: | - |
| Quality Score: | 8.1 |
| Resolution: | 2 Å |
| Missing Residues: | 3 |
| Missing Atoms: | 7 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front gate back | BP-I-A BP-I-B BP-II-out BP-III | Cluster I1 I9 | Ligand No No | Protein Yes Yes |
| Pocket alignment | |
| Uniprot sequence: | RVIGAGEFGEVCSVAIKTLDFLCEASIMGQFDPNVVHLEGVMIVIEFMENGALDAFLRKYLADMGYVHRDLAARNILVVSDFGLS |
| Sequence structure: | RVIGA_EFGEVCSVAIKTLDFLCEASIMGQFDPNVVHLEGVMIVIEFMENGALDAFLRKYLADMGYVHRDLAARNILVVSDFG__ |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL552425 |
| Bioaffinities: | 2 records for 1 kinase |
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | Ephrin type-B receptor 2 | 7 | 7 | 7.4 | pEC50 | 2 |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 R 637 | 2 V 638 | 3 I 639 | 4 G 640 | 5 A 641 | 6 _ _ | 7 E 643 | 8 F 644 | 9 G 645 | 10 E 646 | 11 V 647 | 12 C 648 | 13 S 649 | 14 V 662 | 15 A 663 | 16 I 664 | 17 K 665 | 18 T 666 | 19 L 667 | 20 D 678 |
| • | • | • | • | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 F 679 | 22 L 680 | 23 C 681 | 24 E 682 | 25 A 683 | 26 S 684 | 27 I 685 | 28 M 686 | 29 G 687 | 30 Q 688 | 31 F 689 | 32 D 690 | 33 P 692 | 34 N 693 | 35 V 694 | 36 V 695 | 37 H 696 | 38 L 697 | 39 E 698 | 40 G 699 |
| •• | • | • | • | • | • | ||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 700 | 42 M 708 | 43 I 709 | 44 V 710 | 45 I 711 | 46 E 712 | 47 F 713 | 48 M 714 | 49 E 715 | 50 N 716 | 51 G 717 | 52 A 718 | 53 L 719 | 54 D 720 | 55 A 721 | 56 F 722 | 57 L 723 | 58 R 724 | 59 K 725 | 60 Y 748 |
| • | • | •• | •• | ||||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 749 | 62 A 750 | 63 D 751 | 64 M 752 | 65 G 753 | 66 Y 754 | 67 V 755 | 68 H 756 | 69 R 757 | 70 D 758 | 71 L 759 | 72 A 760 | 73 A 761 | 74 R 762 | 75 N 763 | 76 I 764 | 77 L 765 | 78 V 766 | 79 V 774 | 80 S 775 |
| • | • | • | • | • | |||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 776 | 82 F 777 | 83 G 778 | 84 _ _ | 85 _ _ | |||||||||||||||
| •• | •• | ||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
