PDB-code
| Kinase structure | |
| Kinase: | RIOK2 |
| Family: | RIO |
| Group: | Atypical |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2187 |
| PDB: | 6HK6 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2018-10-24 |
| PubMed: | 30991936 |
| Chain: | J |
| Orthosteric ligand: | G8H |
 | |
| More entries for 6HK6 | |||
| 6HK6 | Chain: | A | |
| 6HK6 | Chain: | B | |
| 6HK6 | Chain: | C | |
| 6HK6 | Chain: | D | |
| 6HK6 | Chain: | E | |
| 6HK6 | Chain: | F | |
| 6HK6 | Chain: | G | |
| 6HK6 | Chain: | H | |
| 6HK6 | Chain: | I | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 43.1° (13.5Å) |
| G-rich loop rotation: | 75° |
| Quality Score: | 9.4 |
| Resolution: | 2.35 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 2 |
| Ligand binding mode | ||||
| Pockets | Subpockets | |||
| front | ||||
| Pocket alignment | |
| Uniprot sequence: | NQMGVGKESDIYIFALKLHSAMKEFAYMKALYFPVPKPIDYAVVMELINGYPLCQIHHVLANHG-LIHGDFNEFNLILMIDFPQM |
| Sequence structure: | NQMGVGKESDIYIFALKLHSAMKEFAYMKALYFPVPKPIDYAVVMELINGYPLCQIHHVLANHG_LIHGDFNEFNLILMIDFPQM |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 N 99 | 2 Q 100 | 3 M 101 | 4 G 102 | 5 V 103 | 6 G 104 | 7 K 105 | 8 E 106 | 9 S 107 | 10 D 108 | 11 I 109 | 12 Y 110 | 13 I 111 | 14 F 120 | 15 A 121 | 16 L 122 | 17 K 123 | 18 L 124 | 19 H 125 | 20 S 157 |
| • | • | • | • | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 A 158 | 22 M 159 | 23 K 160 | 24 E 161 | 25 F 162 | 26 A 163 | 27 Y 164 | 28 M 165 | 29 K 166 | 30 A 167 | 31 L 168 | 32 Y 169 | 33 F 173 | 34 P 174 | 35 V 175 | 36 P 176 | 37 K 177 | 38 P 178 | 39 I 179 | 40 D 180 |
| • | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 Y 181 | 42 A 185 | 43 V 186 | 44 V 187 | 45 M 188 | 46 E 189 | 47 L 190 | 48 I 191 | 49 N 192 | 50 G 193 | 51 Y 194 | 52 P 195 | 53 L 196 | 54 C 197 | 55 Q 198 | 56 I 199 | 57 H 200 | 58 H 201 | 59 V 202 | 60 L 219 |
| • | • | • | ••• | • | |||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 A 220 | 62 N 221 | 63 H 222 | 64 G 223 | 65 _ _ | 66 L 224 | 67 I 225 | 68 H 226 | 69 G 227 | 70 D 228 | 71 F 229 | 72 N 230 | 73 E 231 | 74 F 232 | 75 N 233 | 76 L 234 | 77 I 235 | 78 L 236 | 79 M 244 | 80 I 245 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 246 | 82 F 247 | 83 P 248 | 84 Q 249 | 85 M 250 | |||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
