PDB-code
| Kinase structure | |
| Kinase: | FES |
| Family: | Fer |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2023 |
| PDB: | 6JMF |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2019-06-12 |
| PubMed: | 31097992 |
| Chain: | A |
| Orthosteric ligand: | 9FC |
 | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 54.8° (16.4Å) |
| G-rich loop rotation: | 80° |
| Quality Score: | 9.7 |
| Resolution: | 2 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 3 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | FP-I | Cluster I1 | Ligand No | Protein No |
| Pocket alignment | |
| Uniprot sequence: | EQIGRGNFGEVFSVAVKSCKFLQEARILKQYSPNIVRLIGVYIVMELVQGGDFLTFLRTYLESKCCIHRDLAARNCLVISDFGMS |
| Sequence structure: | EQIGRGNFGEVFSVAVKSCKFLQEARILKQYSPNIVRLIGVYIVMELVQGGDFLTFLRTYLESKCCIHRDLAARNCLVISDFGMS |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 E 565 | 2 Q 566 | 3 I 567 | 4 G 568 | 5 R 569 | 6 G 570 | 7 N 571 | 8 F 572 | 9 G 573 | 10 E 574 | 11 V 575 | 12 F 576 | 13 S 577 | 14 V 587 | 15 A 588 | 16 V 589 | 17 K 590 | 18 S 591 | 19 C 592 | 20 K 603 |
| • | • | • | • | • | •• | ||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 F 604 | 22 L 605 | 23 Q 606 | 24 E 607 | 25 A 608 | 26 R 609 | 27 I 610 | 28 L 611 | 29 K 612 | 30 Q 613 | 31 Y 614 | 32 S 615 | 33 P 617 | 34 N 618 | 35 I 619 | 36 V 620 | 37 R 621 | 38 L 622 | 39 I 623 | 40 G 624 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 625 | 42 Y 633 | 43 I 634 | 44 V 635 | 45 M 636 | 46 E 637 | 47 L 638 | 48 V 639 | 49 Q 640 | 50 G 641 | 51 G 642 | 52 D 643 | 53 F 644 | 54 L 645 | 55 T 646 | 56 F 647 | 57 L 648 | 58 R 649 | 59 T 650 | 60 Y 673 |
| • | • | • | •• | • | • | • | |||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 674 | 62 E 675 | 63 S 676 | 64 K 677 | 65 C 678 | 66 C 679 | 67 I 680 | 68 H 681 | 69 R 682 | 70 D 683 | 71 L 684 | 72 A 685 | 73 A 686 | 74 R 687 | 75 N 688 | 76 C 689 | 77 L 690 | 78 V 691 | 79 I 699 | 80 S 700 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 701 | 82 F 702 | 83 G 703 | 84 M 704 | 85 S 705 | |||||||||||||||
| ••• | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
