Mitogen-activated protein kinase 1
Kinase structure
Kinase:MAPK1 (Erk2)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1495
PDB:6NBS
sc-PDB:
KIDFamMap:Search
Release date:2019-07-31
PubMed: 31058487
Chain:A
(Alternate) Model:B
Click to open a 3D viewer
The orthosteric binding pocket


More entries for 6NBS
6NBSAlternative model: AChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):58.6° (18.2Å)
G-rich loop rotation:49.4°
Quality Score:8
Resolution:1.9 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I2
I5
Ligand
No
No
Protein
No
Yes

Allosteric Ligand
Allosteric ligand:KJ7
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:SYIGEGAYGMVCSVAIKKIRTLREIKILLRFRENIIGINDIYIVQDLME-TDLYKLLKTYIHSANVLHRDLKPSNLLLICDFGLA
Sequence structure:SYIGEGAYGMVCSVAIKKIRTLREIKILLRFRENIIGINDIYIVQDLME_TDLYKLLKTYIHSANVLHRDLKPSNLLLICDFGLA