PDB-code
| Kinase structure | |
| Kinase: | CAMK1G (CaMK1g) |
| Family: | CAMK1 |
| Group: | CAMK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1954 |
| PDB: | 2JAM |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2007-03-13 |
| Chain: | B |
| (Alternate) Model: | B |
| Orthosteric ligand: | J60 |
 | |
| More entries for 2JAM | |||||
| 2JAM | Alternative model: | A | Chain: | A | |
| 2JAM | Alternative model: | A | Chain: | B | |
| 2JAM | Alternative model: | B | Chain: | A | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | out |
| G-rich loop angle (distance): | 50° (15.2Å) |
| G-rich loop rotation: | 50.3° |
| Quality Score: | 9.2 |
| Resolution: | 1.7 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 8 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | Cluster I1 I2 I3 | Ligand No No No | Protein Yes Yes No | |
| Pocket alignment | |
| Uniprot sequence: | EVLGSGAFSEVFLFALKCISLENEIAVLKKIKENIVTLEDIYLVMQLVSGGELFDRILEYLHENGIVHRDLKPENLLYITDFGLS |
| Sequence structure: | EVLGSGAFSEVFLFALKCISLENEIAVLKKIKENIVTLEDIYLVMQLVSGGELFDRILEYLHENGIVHRDLKPENLLYITDFGLS |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL13485 |
| Bioaffinities: | 12 records for 7 kinases |
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | Epidermal growth factor receptor erbB1 | 5.5 | 5.5 | 5.5 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6.8 | 6.8 | 6.8 | pIC50 | 2 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 6.1 | 6.1 | 6.1 | pIC50 | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 8.5 | 5.5 | 8.5 | pIC50 | 3 |
| Homo sapiens | Serine/threonine-protein kinase NEK2 | 5.1 | 5.1 | 5.1 | pIC50 | 1 |
| Homo sapiens | Stem cell growth factor receptor | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 7.6 | 5.5 | 7.6 | pIC50 | 3 |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 E 27 | 2 V 28 | 3 L 29 | 4 G 30 | 5 S 31 | 6 G 32 | 7 A 33 | 8 F 34 | 9 S 35 | 10 E 36 | 11 V 37 | 12 F 38 | 13 L 39 | 14 F 49 | 15 A 50 | 16 L 51 | 17 K 52 | 18 C 53 | 19 I 54 | 20 S 65 |
| • | • | • | • | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 L 66 | 22 E 67 | 23 N 68 | 24 E 69 | 25 I 70 | 26 A 71 | 27 V 72 | 28 L 73 | 29 K 74 | 30 K 75 | 31 I 76 | 32 K 77 | 33 E 79 | 34 N 80 | 35 I 81 | 36 V 82 | 37 T 83 | 38 L 84 | 39 E 85 | 40 D 86 |
| • | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 I 87 | 42 Y 95 | 43 L 96 | 44 V 97 | 45 M 98 | 46 Q 99 | 47 L 100 | 48 V 101 | 49 S 102 | 50 G 103 | 51 G 104 | 52 E 105 | 53 L 106 | 54 F 107 | 55 D 108 | 56 R 109 | 57 I 110 | 58 L 111 | 59 E 112 | 60 Y 134 |
| • | • | • | •• | ||||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 135 | 62 H 136 | 63 E 137 | 64 N 138 | 65 G 139 | 66 I 140 | 67 V 141 | 68 H 142 | 69 R 143 | 70 D 144 | 71 L 145 | 72 K 146 | 73 P 147 | 74 E 148 | 75 N 149 | 76 L 150 | 77 L 151 | 78 Y 152 | 79 I 163 | 80 T 164 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 165 | 82 F 166 | 83 G 167 | 84 L 168 | 85 S 169 | |||||||||||||||
| • | |||||||||||||||||||
Interaction pattern search
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