Leucine-rich repeat kinase 2
Kinase structure
Kinase:LRRK2
Family:LRRK
Group:TKL
Species:HUMAN
IUPHAR/BPS ID:2059
PDB:7LHT
sc-PDB:
KIDFamMap:Search
Release date:2021-06-16
PubMed: 34107286
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:out
αC-helix conformation:out
G-rich loop angle (distance):94.8° (90.9Å)
G-rich loop rotation:40.8°
Quality Score:4
Resolution:3.5 Å
Missing Residues:0
Missing Atoms:0

Allosteric Ligand
Allosteric ligand:ATP
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:ADHGDGSFGSVYRVAVKIFLLRQELVVLCHLHPSLISLLAAMLVMELASKGSLDRLLQQYLHSAMIIYRDLKPHNVLLIADYGIA
Sequence structure:KALGKGLFSMVIRITLKVVGLRILNLPHLILEYCKAKDIIRFLQQKNFLLLINWGIR