Mitogen-activated protein kinase 12
Kinase structure
Kinase:MAPK12 (p38g)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1501
PDB:7CGA
sc-PDB:
KIDFamMap:Search
Release date:2021-06-30
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):54.4° (15.6Å)
G-rich loop rotation:59.8°
Quality Score:8
Resolution:3.15 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I2
I5
I6
I10
Ligand
No
No
No
No
Protein
Yes
Yes
No
Yes

Pocket alignment
Uniprot sequence:QPVGSGAYGAVCSVAIKKLRAYRELRLLKHMRENVIGLLDVYLVMPFMG-TDLGKLMKHYIHAAGIIHRDLKPGNLAVILDFGLA
Sequence structure:QPVGSGAYGAVCSVAIKKLRAYRELRLLKHMRENVIGLLDVYLVMPFMG_TDLGKLMKHYIHAAGIIHRDLKPGNLAVILDFGLA