Pim-1 proto-oncogene, serine/threonine kinase
Kinase structure
Kinase:PIM1
Family:PIM
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2158
PDB:7OOW
sc-PDB:
KIDFamMap:Search
Release date:2021-08-04
PubMed: 34299628
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):54.5° (16.5Å)
G-rich loop rotation:40.5°
Quality Score:8
Resolution:1.95 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I4
I5
Ligand
No
No
No
Protein
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:PLLGSGGFGSVYSVAIKHVRVPMEVVLLKKVSSGVIRLLDWVLILERPEVQDLFDFITEHCHNCGVLHRDIKDENILILIDFGSG
Sequence structure:PLLGSGGFGSVYSVAIKHVRVPMEVVLLKKVSSGVIRLLDWVLILERPEVQDLFDFITEHCHNCGVLHRDIKDENILILIDFGSG