Protein tyrosine kinase 2
Kinase structure
Kinase:PTK2 (FAK)
Family:FAK
Group:TK
Species:HUMAN
IUPHAR/BPS ID:2180
PDB:7PI4
sc-PDB:
KIDFamMap:Search
Release date:2021-09-29
PubMed: 34416073
Chain:D
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 7PI4
7PI4Alternative model: AChain: D


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):65.9° (19.5Å)
G-rich loop rotation:86.8°
Quality Score:8
Resolution:2.24 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I3
Ligand
No
No
Protein
Yes
No

Pocket alignment
Uniprot sequence:RCIGEGQFGDVHQVAIKTCKFLQEALTMRQFDPHIVKLIGVWIIMELCTLGELRSFLQVYLESKRFVHRDIAARNVLVLGDFGLS
Sequence structure:RCIGEGQFGDVHQVAIKTCKFLQEALTMRQFDPHIVKLIGVWIIMELCTLGELRSFLQVYLESKRFVHRDIAARNVLVLGDFGLS