Epidermal growth factor receptor
Kinase structure
Kinase:EGFR
Family:EGFR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1797
PDB:7TVD
sc-PDB:
KIDFamMap:Search
Release date:2022-02-16
PubMed: 36357385
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):66.4° (20.4Å)
G-rich loop rotation:35.7°
Quality Score:7.6
Resolution:2.96 Å
Missing Residues:1
Missing Atoms:0

Pocket alignment
Uniprot sequence:KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLITQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA
Sequence structure:KVLGSGAFGTVYKVAIKE_EILDEAYVMASVDPHVCRLLGIQLITQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA