Mitogen-activated protein kinase 1
Kinase structure
Kinase:MAPK1 (Erk2)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1495
PDB:7E73
sc-PDB:
KIDFamMap:Search
Release date:2022-03-02
Chain:A
Click to open a 3D viewer
The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):58° (17.3Å)
G-rich loop rotation:42.7°
Quality Score:8
Resolution:2.28 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I5
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:SYIGEGAYGMVCSVAIKKIRTLREIKILLRFRENIIGINDIYIVQDLME-TDLYKLLKTYIHSANVLHRDLKPSNLLLICDFGLA
Sequence structure:SYIGEGAHGMVCSVAIKKIRTLREIKILLRFRENIIGINDIYIVQDLME_TDLYKLLKTYIHSANVLHRDLKPSNLLLICDFGLA