Mitogen-activated protein kinase 1
Kinase structure
Kinase:MAPK1 (Erk2)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1495
PDB:7E75
sc-PDB:
KIDFamMap:Search
Release date:2022-03-02
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):58° (17.8Å)
G-rich loop rotation:48.1°
Quality Score:8
Resolution:2.481 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I5
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:SYIGEGAYGMVCSVAIKKIRTLREIKILLRFRENIIGINDIYIVQDLME-TDLYKLLKTYIHSANVLHRDLKPSNLLLICDFGLA
Sequence structure:SYIGEGAYCMVCSVAIKKIRTLREIKILLRFRENIIGINDIYIVQDLME_TDLYKLLKTYIHSANVLHRDLKPSNLLLICDFGLA