PDB-code
| Kinase structure | |
| Kinase: | STK25 (YSK1) |
| Family: | STE20 |
| Group: | STE |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2218 |
| PDB: | 7Z4V |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2022-04-06 |
| PubMed: | 36030002 |
| Chain: | A |
| (Alternate) Model: | A |
| Orthosteric ligand: | IB5 |
 | |
| More entries for 7Z4V | |||||
| 7Z4V | Alternative model: | B | Chain: | A | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | - |
| G-rich loop rotation: | - |
| Quality Score: | 7.2 |
| Resolution: | 1.644 Å |
| Missing Residues: | 2 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | Cluster I3 I5 I10 | Ligand No No No | Protein Yes Yes Yes | |
| Pocket alignment | |
| Uniprot sequence: | DRIGKGSFGEVYKVAIKIIDIQQEITVLSQCDPYITRYFGSWIIMEYLGGGSALDLLKPYLHSERKIHRDIKAANVLLLADFGVA |
| Sequence structure: | DRIG__SFGEVYKVAIKIIDIQQEITVLSQCDPYITRYFGSWIIMEYLGGGSALDLLKPYLHSERKIHRDIKAANVLLLADFGVA |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 D 24 | 2 R 25 | 3 I 26 | 4 G 27 | 5 _ _ | 6 _ _ | 7 S 30 | 8 F 31 | 9 G 32 | 10 E 33 | 11 V 34 | 12 Y 35 | 13 K 36 | 14 V 46 | 15 A 47 | 16 I 48 | 17 K 49 | 18 I 50 | 19 I 51 | 20 D 62 |
| • | • | • | |||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 I 63 | 22 Q 64 | 23 Q 65 | 24 E 66 | 25 I 67 | 26 T 68 | 27 V 69 | 28 L 70 | 29 S 71 | 30 Q 72 | 31 C 73 | 32 D 74 | 33 P 76 | 34 Y 77 | 35 I 78 | 36 T 79 | 37 R 80 | 38 Y 81 | 39 F 82 | 40 G 83 |
| • | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 S 84 | 42 W 92 | 43 I 93 | 44 I 94 | 45 M 95 | 46 E 96 | 47 Y 97 | 48 L 98 | 49 G 99 | 50 G 100 | 51 G 101 | 52 S 102 | 53 A 103 | 54 L 104 | 55 D 105 | 56 L 106 | 57 L 107 | 58 K 108 | 59 P 109 | 60 Y 130 |
| • | • | • | ••• | • | • | • | • | • | |||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 131 | 62 H 132 | 63 S 133 | 64 E 134 | 65 R 135 | 66 K 136 | 67 I 137 | 68 H 138 | 69 R 139 | 70 D 140 | 71 I 141 | 72 K 142 | 73 A 143 | 74 A 144 | 75 N 145 | 76 V 146 | 77 L 147 | 78 L 148 | 79 L 156 | 80 A 157 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 158 | 82 F 159 | 83 G 160 | 84 V 161 | 85 A 162 | |||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
