Mitogen-activated protein kinase 1
Kinase structure
Kinase:MAPK1 (Erk2)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1495
PDB:8AOJ
sc-PDB:
KIDFamMap:Search
Release date:2022-09-28
PubMed: 36101934
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 8AOJ
8AOJAlternative model: AChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):62.8° (18.3Å)
G-rich loop rotation:74.5°
Quality Score:8
Resolution:1.12 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I5
I10
Ligand
No
No
Protein
Yes
Yes

Pocket alignment
Uniprot sequence:SYIGEGAYGMVCSVAIKKIRTLREIKILLRFRENIIGINDIYIVQDLME-TDLYKLLKTYIHSANVLHRDLKPSNLLLICDFGLA
Sequence structure:SYIGEGAYGMVCSVAIKKIRTLREIKILLRFRENIIGINDIYIVQDLME_TDLYKLLKTYIHSANVLHRDLKPSNLLLICDFGLA