Janus kinase 1
Kinase structure
Kinase:Jak1 (JAK1)
Family:JakA
Group:TK
Species:MOUSE
PDB:8EWY
sc-PDB:
KIDFamMap:Search
Release date:2023-03-08
PubMed: 36867534
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:out
G-rich loop angle (distance):138.6° (71.2Å)
G-rich loop rotation:59°
Quality Score:4
Resolution:5.5 Å
Missing Residues:0
Missing Atoms:213

Allosteric Ligand
Allosteric ligand:ADN
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:RDLGEGHFGKVELVAVKSLDLKKEIEILRNLYENIVKYKGIKLIMEFLPSGSLKEYLPKYLGSRQYVHRDLAARNVLVIGDFGLT
Sequence structure:GSGNFGSVQKVAVKSAFNLYEIYKGILIMEFLPGSLKYLPKLT