PDB-code
| Kinase structure | |
| Kinase: | PRKCH (PKCh) |
| Family: | PKC |
| Group: | AGC |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1487 |
| PDB: | 8FP3 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2023-04-05 |
| PubMed: | 36940470 |
| Chain: | A |
| (Alternate) Model: | A |
| Orthosteric ligand: | Y3I |
 | |
| More entries for 8FP3 | |||||
| 8FP3 | Alternative model: | B | Chain: | A | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 54.3° (16.7Å) |
| G-rich loop rotation: | 48.5° |
| Quality Score: | 8 |
| Resolution: | 2.3 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | Cluster I1 I2 I4 I5 | Ligand No No No No | Protein Yes Yes Yes Yes | |
| Pocket alignment | |
| Uniprot sequence: | RVLGKGSFGKVMLYAVKVLCTMTEKRILSLARPFLTQLFCCFFVMEFVNGGDLMFHIQKFLHDKGIIYRDLKLDNVLLLADFGMC |
| Sequence structure: | RVLGKGSFGKVMLYAVKVLCTMTEKRILSLARPFLTQLFCCFFVMEFVNGGDLMFHIQKFLHDKGIIYRDLKLDNVLLLADFGMC |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 R 359 | 2 V 360 | 3 L 361 | 4 G 362 | 5 K 363 | 6 G 364 | 7 S 365 | 8 F 366 | 9 G 367 | 10 K 368 | 11 V 369 | 12 M 370 | 13 L 371 | 14 Y 381 | 15 A 382 | 16 V 383 | 17 K 384 | 18 V 385 | 19 L 386 | 20 C 399 |
| • | • | • | • | • | |||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 T 400 | 22 M 401 | 23 T 402 | 24 E 403 | 25 K 404 | 26 R 405 | 27 I 406 | 28 L 407 | 29 S 408 | 30 L 409 | 31 A 410 | 32 R 411 | 33 P 414 | 34 F 415 | 35 L 416 | 36 T 417 | 37 Q 418 | 38 L 419 | 39 F 420 | 40 C 421 |
| • | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 C 422 | 42 F 430 | 43 F 431 | 44 V 432 | 45 M 433 | 46 E 434 | 47 F 435 | 48 V 436 | 49 N 437 | 50 G 438 | 51 G 439 | 52 D 440 | 53 L 441 | 54 M 442 | 55 F 443 | 56 H 444 | 57 I 445 | 58 Q 446 | 59 K 447 | 60 F 469 |
| • | • | •• | •• | ||||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 470 | 62 H 471 | 63 D 472 | 64 K 473 | 65 G 474 | 66 I 475 | 67 I 476 | 68 Y 477 | 69 R 478 | 70 D 479 | 71 L 480 | 72 K 481 | 73 L 482 | 74 D 483 | 75 N 484 | 76 V 485 | 77 L 486 | 78 L 487 | 79 L 495 | 80 A 496 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 497 | 82 F 498 | 83 G 499 | 84 M 500 | 85 C 501 | |||||||||||||||
| • | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
