PDB-code
| Kinase structure | |
| Kinase: | EGFR |
| Family: | EGFR |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1797 |
| PDB: | 8DSW |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2023-09-27 |
| Chain: | A |
| Orthosteric ligand: | ANP |
 | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | - |
| G-rich loop rotation: | - |
| Quality Score: | 6.4 |
| Resolution: | 2.39 Å |
| Missing Residues: | 4 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | FP-II | Cluster I4 | Ligand No | Protein Yes |
| Pocket alignment | |
| Uniprot sequence: | KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLITQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA |
| Sequence structure: | KVLGS___GTVYKVAIKELEILDEAFQEAYV_PHVCRLLGIQLITQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL1230989 |
| Bioaffinities: | No (p)Ki/(p)IC50/(p)EC50 values for kinases found (confidence ≥ 8). |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 K 716 | 2 V 717 | 3 L 718 | 4 G 719 | 5 S 720 | 6 _ _ | 7 _ _ | 8 _ _ | 9 G 724 | 10 T 725 | 11 V 726 | 12 Y 727 | 13 K 728 | 14 V 742 | 15 A 743 | 16 I 744 | 17 K 745 | 18 E 746 | 19 L 747 | 20 E 758 |
| • | • | • | • | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 I 759 | 22 L 760 | 23 D 761 | 24 E 762 | 25 A 763 | 26 F 764 | 27 Q 765 | 28 E 766 | 29 A 767 | 30 Y 768 | 31 V 769 | 32 _ _ | 33 P 776 | 34 H 777 | 35 V 778 | 36 C 779 | 37 R 780 | 38 L 781 | 39 L 782 | 40 G 783 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 I 784 | 42 Q 791 | 43 L 792 | 44 I 793 | 45 T 794 | 46 Q 795 | 47 L 796 | 48 M 797 | 49 P 798 | 50 F 799 | 51 G 800 | 52 C 801 | 53 L 802 | 54 L 803 | 55 D 804 | 56 Y 805 | 57 V 806 | 58 R 807 | 59 E 808 | 60 Y 831 |
| • | • | •• | |||||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 832 | 62 E 833 | 63 D 834 | 64 R 835 | 65 R 836 | 66 L 837 | 67 V 838 | 68 H 839 | 69 R 840 | 70 D 841 | 71 L 842 | 72 A 843 | 73 A 844 | 74 R 845 | 75 N 846 | 76 V 847 | 77 L 848 | 78 V 849 | 79 I 857 | 80 T 858 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 859 | 82 F 860 | 83 G 861 | 84 L 862 | 85 A 863 | |||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
