P21 protein (Cdc42/Rac)-activated kinase 7
Kinase structure
Kinase:PAK5
Family:STE20
Group:STE
Species:HUMAN
IUPHAR/BPS ID:2138
PDB:8C12
sc-PDB:
KIDFamMap:Search
Release date:2023-10-25
PubMed: 37776520
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 8C12
8C12Alternative model: AChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):57.7° (17.4Å)
G-rich loop rotation:53°
Quality Score:8
Resolution:1.549 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I2
I5
I8
I11
Ligand
No
No
No
No
No
Protein
Yes
No
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:IKIGEGSTGIVCIVAVKKMLLFNEVVIMRDYHDNVVDMYSSWVVMEFLEGGALTDIVTHYLHNQGVIHRDIKSDSILLLSDFGFC
Sequence structure:IKIGEGSTGIVCIVAVKKMLLFNEVVIMRDYHDNVVDMYSSWVVMEFLEGGALTDIVTHYLHNQGVIHRDIKSDSILLLSDFGFC