Leucine-rich repeat kinase 2
Kinase structure
Kinase:LRRK2
Family:LRRK
Group:TKL
Species:HUMAN
IUPHAR/BPS ID:2059
PDB:8TZB
sc-PDB:
KIDFamMap:Search
Release date:2023-12-06
PubMed: 38039358
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:out
αC-helix conformation:out
G-rich loop angle (distance):124.1° (58.4Å)
G-rich loop rotation:149.6°
Quality Score:3.6
Resolution:3.1 Å
Missing Residues:1
Missing Atoms:0

Allosteric Ligand
Allosteric ligand:T3X
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:ADHGDGSFGSVYRVAVKIFLLRQELVVLCHLHPSLISLLAAMLVMELASKGSLDRLLQQYLHSAMIIYRDLKPHNVLLIADYGIA
Sequence structure:LVGKACMSKITKASLKIIKLVRENQILSSLDIIIRLYEMYLVLDFLKKWALYSFLVNLLHSLRILHRDLKPHNVLLI_