Leucine-rich repeat kinase 2
Kinase structure
Kinase:LRRK2
Family:LRRK
Group:TKL
Species:HUMAN
IUPHAR/BPS ID:2059
PDB:8TZG
sc-PDB:
KIDFamMap:Search
Release date:2023-12-06
PubMed: 38039358
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 8TZG
8TZGAlternative model: AChain: A


Structural information
DFG conformation:out-like
αC-helix conformation:out
G-rich loop angle (distance):60.4° (47.9Å)
G-rich loop rotation:155°
Quality Score:2.4
Resolution:2.7 Å
Missing Residues:4
Missing Atoms:0

Allosteric Ligand
Allosteric ligand:A1N
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:ADHGDGSFGSVYRVAVKIFLLRQELVVLCHLHPSLISLLAAMLVMELASKGSLDRLLQQYLHSAMIIYRDLKPHNVLLIADYGIA
Sequence structure:__LVGAIRL__EVLNESRLLSSLDPYLLEMYSFYLILEAPEGEIFNLLRQYLHSAMIIYRDLKPHNVLFIADYGTA