Microtubule affinity regulating kinase 4
Kinase structure
Kinase:MARK4
Family:CAMKL
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2100
PDB:8XFL
sc-PDB:
KIDFamMap:Search
Release date:2023-12-27
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:out
G-rich loop angle (distance):58.8° (17Å)
G-rich loop rotation:45°
Quality Score:8
Resolution:3 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I5
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:RTIGKGNFAKVKLVAIKIIKLFREVRIMKGLNPNIVKLFEVYLVMEYASAGEVFDYLVSYCHQKNIVHRDLKAENLLLIADFGFS
Sequence structure:RTIGKGNFAKVKLVAIKIIKLFREVRIMKGLNPNIVKLFEVYLVMEYASAGEVFDYLVSYCHQKNIVHRDLKAENLLLIADFGFS