Platelet derived growth factor receptor alpha
Kinase structure
Kinase:PDGFRA (PDGFRa)
Family:PDGFR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1803
PDB:8PQK
sc-PDB:
KIDFamMap:Search
Release date:2023-12-27
PubMed: 38167404
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 8PQK
8PQKAlternative model: AChain: A


Structural information
DFG conformation:out
αC-helix conformation:in
G-rich loop angle (distance):62.4° (18.9Å)
G-rich loop rotation:47.2°
Quality Score:7.2
Resolution:2 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I5
I8
Ligand
No
No
No
Protein
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:RVLGSGAFGKVVEVAVKMLALMSELKIMTHLGLNIVNLLGAYIITEYCFYGDLVNYLHKFLASKNCVHRDLAARNVLLICDFGLA
Sequence structure:RVLGSGAFGKVVEVAVKMLALMSELKIMTHLGLNIVNLLGAYIIIEYCFYGDLVNYLHKFLASKNCVHRDLAARNVLLICDFGLA