Version: 3.2
Updated: 29-Oct-2025
Protein tyrosine kinase 2 beta
Kinase structure
Kinase:PTK2B (PYK2)
Family:FAK
Group:TK
Species:HUMAN
IUPHAR/BPS ID:2181
PDB:8XOX
sc-PDB:
KIDFamMap:Search
Release date:2024-01-24
Chain:A
(Alternate) Model:B
Orthosteric ligand:YAM
2D structure of the orthosteric ligand
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The orthosteric binding pocket


More entries for 8XOX
8XOXAlternative model: AChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):63° (18.4Å)
G-rich loop rotation:74.6°
Quality Score:8
Resolution:1.9 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
PocketsSubpocketsWaters
front
FP-II
Cluster
I1
I11
Ligand
No
Yes
Protein
Yes
Yes

Pocket alignment
Uniprot sequence:RILGEGFFGEVYEVAVKTCKFMSEAVIMKNLDPHIVKLIGIWIIMELYPYGELGHYLERYLESINCVHRDIAVRNILVLGDFGLS
Sequence structure:RILGEGFFGEVYEVAVKTCKFMSEAVIMKNLDPHIVKLIGIWIIMELYPYGELGHYLERYLESINCVHRDIAVRNILVLGDFGLS

Ligand affinity
ChEMBL ID:CHEMBL1084546
Bioaffinities: 115 records for 103 kinases
Species Kinase (ChEMBL naming) Median Min Max Type Records
Homo sapiens3-phosphoinositide dependent protein kinase-1666pKi1
Homo sapiensALK tyrosine kinase receptor6.76.76.7pKi1
Homo sapiensAMP-activated protein kinase, alpha-1 subunit6.46.46.4pKi1
Homo sapiensBR serine/threonine-protein kinase 15.35.35.3pKi1
Homo sapiensCaM kinase II delta5.45.45.4pKi1
Homo sapiensCaM kinase II gamma5.65.65.6pKi1
Homo sapiensCaM-kinase kinase beta6.56.56.5pKi1
Homo sapienscAMP-dependent protein kinase alpha-catalytic subunit6.86.86.8pKi1
Homo sapiensCasein kinase I gamma 15.45.45.4pKi1
Homo sapiensCasein kinase I gamma 25.45.45.4pKi1
Homo sapiensCasein kinase II alpha666pKi1
Homo sapiensc-Jun N-terminal kinase 25.85.85.8pKi1
Homo sapiensc-Jun N-terminal kinase 36.66.66.6pKi1
Homo sapiensCyclin-dependent kinase 17.27.27.2pKi1
Homo sapiensCyclin-dependent kinase 27.17.17.1pKi1
Homo sapiensCyclin-dependent kinase 57.87.87.8pKi1
Homo sapiensCyclin-dependent kinase 77.77.77.7pKi1
Homo sapiensCyclin-dependent kinase 97.27.27.2pKi1
Homo sapiensDeath-associated protein kinase 3666pKi1
Homo sapiensDual specificity mitogen-activated protein kinase kinase 25.65.65.6pKi1
Homo sapiensDual specificity protein kinase CLK26.96.96.9pKi1
Homo sapiensDual specificity protein kinase CLK47.27.27.2pKi1
Homo sapiensEphrin type-A receptor 25.95.95.9pKi1
Homo sapiensFibroblast growth factor receptor 16.26.26.2pKi1
Homo sapiensFibroblast growth factor receptor 36.26.26.2pKi1
Homo sapiensFocal adhesion kinase 18.88.89pIC505
Homo sapiensFocal adhesion kinase 19.29.29.2pKi1
Homo sapiensGlycogen synthase kinase-3 alpha7.17.17.1pKi1
Homo sapiensGlycogen synthase kinase-3 beta777pKi1
Homo sapiensG protein-coupled receptor kinase 55.65.65.6pKi1
Homo sapiensHepatocyte growth factor receptor6.66.66.6pKi1
Homo sapiensHomeodomain-interacting protein kinase 26.76.76.7pKi1
Homo sapiensHomeodomain-interacting protein kinase 46.36.36.3pKi1
Homo sapiensInsulin-like growth factor I receptor6.16.16.1pKi1
Homo sapiensInsulin receptor6.36.36.3pKi1
Homo sapiensInterleukin-1 receptor-associated kinase 15.75.75.7pKi1
Homo sapiensInterleukin-1 receptor-associated kinase 46.46.46.4pKi1
Homo sapiensLeucine-rich repeat serine/threonine-protein kinase 26.86.86.8pKi1
Homo sapiensLeukocyte tyrosine kinase receptor6.56.56.5pKi1
Homo sapiensMacrophage-stimulating protein receptor6.66.66.6pKi1
Homo sapiensMAP kinase ERK27.27.27.2pKi1
Homo sapiensMAP kinase p38 gamma5.65.65.6pKi1
Homo sapiensMAP/microtubule affinity-regulating kinase 26.56.56.5pKi1
Homo sapiensMAP/microtubule affinity-regulating kinase 47.37.37.3pKi1
Homo sapiensMaternal embryonic leucine zipper kinase7.17.17.1pKi1
Homo sapiensMisshapen-like kinase 16.26.26.2pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase 106.76.76.7pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 25.85.85.8pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 46.26.26.2pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 56.96.96.9pKi1
Homo sapiensMixed lineage kinase 75.35.35.3pKi1
Homo sapiensNerve growth factor receptor Trk-A6.46.46.4pKi1
Homo sapiensNeurotrophic tyrosine kinase receptor type 27.47.47.4pKi1
Homo sapiensPlatelet-derived growth factor receptor beta666pKi1
Homo sapiensProtein kinase C delta5.85.85.8pKi1
Homo sapiensProtein kinase C gamma5.25.25.2pKi1
Homo sapiensProtein kinase C nu5.95.95.9pKi1
Homo sapiensProtein kinase C theta6.46.46.4pKi1
Homo sapiensProtein kinase N26.16.16.1pKi1
Homo sapiensProtein tyrosine kinase 2 beta7.97.97.9pIC503
Homo sapiensProtein tyrosine kinase 2 beta8.58.58.5pKi1
Homo sapiensProto-oncogene tyrosine-protein kinase ROS7.97.97.9pKi1
Homo sapiensRho-associated protein kinase 15.75.75.7pKi1
Homo sapiensRho-associated protein kinase 25.75.75.7pKi1
Homo sapiensRibosomal protein S6 kinase 15.55.55.5pKi1
Homo sapiensRibosomal protein S6 kinase alpha 36.36.36.3pKi2
Homo sapiensSerine/threonine-protein kinase 17A5.95.95.9pKi1
Homo sapiensSerine/threonine-protein kinase 26.66.66.6pKi1
Homo sapiensSerine/threonine-protein kinase Aurora-A6.96.96.9pKi1
Homo sapiensSerine/threonine-protein kinase Aurora-B7.27.27.2pKi1
Homo sapiensSerine/threonine-protein kinase Chk26.16.16.1pKi1
Homo sapiensSerine/threonine-protein kinase c-TAK16.76.76.7pKi1
Homo sapiensSerine/threonine-protein kinase D25.95.95.9pKi1
Homo sapiensSerine/threonine-protein kinase MRCK-A5.25.25.2pKi1
Homo sapiensSerine/threonine-protein kinase MST26.36.36.3pKi1
Homo sapiensSerine/threonine-protein kinase PAK 15.45.45.4pKi1
Homo sapiensSerine/threonine-protein kinase PAK 46.76.76.7pKi1
Homo sapiensSerine/threonine-protein kinase PLK46.26.26.2pKi1
Homo sapiensSerine/threonine-protein kinase PRKX6.16.16.1pKi1
Homo sapiensSerine/threonine-protein kinase Sgk25.65.65.6pKi1
Homo sapiensSerine/threonine-protein kinase SIK26.76.76.7pKi1
Homo sapiensSerine/threonine-protein kinase SRPK15.85.85.8pKi1
Homo sapiensSerine/threonine-protein kinase TAO16.76.76.7pKi1
Homo sapiensSerine/threonine-protein kinase TBK15.75.75.7pKi1
Homo sapiensTestis-specific serine/threonine-protein kinase 15.85.85.8pKi1
Homo sapiensTyrosine kinase non-receptor protein 25.95.95.9pKi1
Homo sapiensTyrosine-protein kinase BLK6.46.46.4pKi1
Homo sapiensTyrosine-protein kinase BTK5.75.75.7pKi1
Homo sapiensTyrosine-protein kinase CTK777pKi1
Homo sapiensTyrosine-protein kinase FRK7.47.47.4pKi1
Homo sapiensTyrosine-protein kinase FYN5.75.75.7pKi1
Homo sapiensTyrosine-protein kinase HCK5.55.55.5pKi1
Homo sapiensTyrosine-protein kinase ITK/TSK7.17.17.1pKi1
Homo sapiensTyrosine-protein kinase JAK27.17.17.1pKi2
Homo sapiensTyrosine-protein kinase JAK3666pKi2
Homo sapiensTyrosine-protein kinase LCK6.36.36.3pKi1
Homo sapiensTyrosine-protein kinase Lyn777pKi1
Homo sapiensTyrosine-protein kinase receptor FLT36.46.46.4pKi1
Homo sapiensTyrosine-protein kinase receptor RET6.56.56.5pKi1
Homo sapiensTyrosine-protein kinase receptor UFO6.76.76.7pKi1
Homo sapiensTyrosine-protein kinase SRC6.36.36.3pKi1
Homo sapiensTyrosine-protein kinase TYK26.56.56.5pKi2
Homo sapiensVascular endothelial growth factor receptor 16.16.16.1pKi1
Homo sapiensVascular endothelial growth factor receptor 26.46.46.4pKi1
Homo sapiensVascular endothelial growth factor receptor 36.66.66.6pKi1


Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
I g.l II III αC
1 R
429		2 I
430		3 L
431		4 G
432		5 E
433		6 G
434		7 F
435		8 F
436		9 G
437		10 E
438		11 V
439		12 Y
440		13 E
441		14 V
454		15 A
455		16 V
456		17 K
457		18 T
458		19 C
459		20 K
470
••••••
αC b.l IV
21 F
471		22 M
472		23 S
473		24 E
474		25 A
475		26 V
476		27 I
477		28 M
478		29 K
479		30 N
480		31 L
481		32 D
482		33 P
484		34 H
485		35 I
486		36 V
487		37 K
488		38 L
489		39 I
490		40 G
491
•
IV V GK hinge linker αD αE
41 I
492		42 W
499		43 I
500		44 I
501		45 M
502		46 E
503		47 L
504		48 Y
505		49 P
506		50 Y
507		51 G
508		52 E
509		53 L
510		54 G
511		55 H
512		56 Y
513		57 L
514		58 E
515		59 R
516		60 Y
539
••••••••••
αE VI c.l VII VIII x
61 L
540		62 E
541		63 S
542		64 I
543		65 N
544		66 C
545		67 V
546		68 H
547		69 R
548		70 D
549		71 I
550		72 A
551		73 V
552		74 R
553		75 N
554		76 I
555		77 L
556		78 V
557		79 L
565		80 G
566
•
DFG a.l
81 D
567		82 F
568		83 G
569		84 L
570		85 S
571

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