Leucine-rich repeat kinase 2
Kinase structure
Kinase:LRRK2
Family:LRRK
Group:TKL
Species:HUMAN
IUPHAR/BPS ID:2059
PDB:8U8B
sc-PDB:
KIDFamMap:Search
Release date:2024-01-31
PubMed: 38263358
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:out-like
αC-helix conformation:out
G-rich loop angle (distance):20.9° (54.3Å)
G-rich loop rotation:42.2°
Quality Score:5.2
Resolution:3.7 Å
Missing Residues:0
Missing Atoms:8

Allosteric Ligand
Allosteric ligand:919
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:ADHGDGSFGSVYRVAVKIFLLRQELVVLCHLHPSLISLLAAMLVMELASKGSLDRLLQQYLHSAMIIYRDLKPHNVLLIADYGIA
Sequence structure:LIGKGDSARLDYLVVGRLLQLVREP