Version: 3.2
Updated: 24-Dec-2025
Casein kinase 1 epsilon
Kinase structure
Kinase:CSNK1E (CK1e)
Family:CK1
Group:CK1
Species:HUMAN
IUPHAR/BPS ID:1998
PDB:4HOK
sc-PDB:
KIDFamMap:Search
Release date:2012-11-14
PubMed: 23106386
Chain:M
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The orthosteric binding pocket


More entries for 4HOK
4HOKChain: A
4HOKChain: C
4HOKChain: E
4HOKChain: G
4HOKChain: I
4HOKChain: K
4HOKChain: O
4HOKChain: Q
4HOKChain: S
4HOKChain: U
4HOKChain: W


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):46.6° (15.1Å)
G-rich loop rotation:74.5°
Quality Score:9
Resolution:2.77 Å
Missing Residues:0
Missing Atoms:10
Ligand binding mode
Waters
Cluster
I11
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:RKIGSGSFGDIYLVAIKLEQLHIESKFYKMMQVGIPSIKWCVMVMELLG-PSLEDLFNFYIHSKNFIHRDVKPDNFLMIIDFGLA
Sequence structure:RKIGSGSFGDIYLVAIKLEQLHIESKFYKMMQVGIPSIKWCVMVMELLG_PSLEDLFNFYIHSKNFIHRDVKPDNFLMIIDFGLA