PDB-code
| Kinase structure | |
| Kinase: | STK11 (LKB1) |
| Family: | CAMKL |
| Group: | CAMK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2212 |
| PDB: | 2WTK |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2009-12-15 |
| PubMed: | 19892943 |
| Chain: | F |
| Orthosteric ligand: | ANP |
 | |
| More entries for 2WTK | |||
| 2WTK | Chain: | B | |
| 2WTK | Chain: | C | |
| 2WTK | Chain: | E | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 53.7° (16.1Å) |
| G-rich loop rotation: | 68.1° |
| Quality Score: | 8 |
| Resolution: | 2.65 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | |||
| front | FP-II | |||
| Pocket alignment | |
| Uniprot sequence: | DLLGEGSYGKVKERAVKILNVKKEIQLLRRLRKNVIQLVDVYMVMEYCVCGMQEMLDSVYLHSQGIVHKDIKPGNLLLISDLGVA |
| Sequence structure: | DLLGEGSYGKVKERAVKILNVKKEIQLLRRLRKNVIQLVDVYMVMEYCVCGMQEMLDSVYLHSQGIVHKDIKPGNLLLISALGVA |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL1230989 |
| Bioaffinities: | No (p)Ki/(p)IC50/(p)EC50 values for kinases found (confidence ≥ 8). |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 D 53 | 2 L 54 | 3 L 55 | 4 G 56 | 5 E 57 | 6 G 58 | 7 S 59 | 8 Y 60 | 9 G 61 | 10 K 62 | 11 V 63 | 12 K 64 | 13 E 65 | 14 R 75 | 15 A 76 | 16 V 77 | 17 K 78 | 18 I 79 | 19 L 80 | 20 N 94 |
| • | • | • | • | •• | •• | • | • | ||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 V 95 | 22 K 96 | 23 K 97 | 24 E 98 | 25 I 99 | 26 Q 100 | 27 L 101 | 28 L 102 | 29 R 103 | 30 R 104 | 31 L 105 | 32 R 106 | 33 K 108 | 34 N 109 | 35 V 110 | 36 I 111 | 37 Q 112 | 38 L 113 | 39 V 114 | 40 D 115 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 116 | 42 Y 126 | 43 M 127 | 44 V 128 | 45 M 129 | 46 E 130 | 47 Y 131 | 48 C 132 | 49 V 133 | 50 C 134 | 51 G 135 | 52 M 136 | 53 Q 137 | 54 E 138 | 55 M 139 | 56 L 140 | 57 D 141 | 58 S 142 | 59 V 143 | 60 Y 166 |
| • | • | •• | • | ||||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 167 | 62 H 168 | 63 S 169 | 64 Q 170 | 65 G 171 | 66 I 172 | 67 V 173 | 68 H 174 | 69 K 175 | 70 D 176 | 71 I 177 | 72 K 178 | 73 P 179 | 74 G 180 | 75 N 181 | 76 L 182 | 77 L 183 | 78 L 184 | 79 I 192 | 80 S 193 |
| • | |||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 A 194 | 82 L 195 | 83 G 196 | 84 V 197 | 85 A 198 | |||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
