MAP kinase interacting serine/threonine kinase 1
Kinase structure
Kinase:MKNK1 (MNK1)
Family:MAPKAPK
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2104
PDB:2HW6
sc-PDB:
KIDFamMap:Search
Release date:2006-08-29
PubMed: 16917500
Chain:A
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The orthosteric binding pocket


More entries for 2HW6
2HW6Chain: B


Structural information
DFG conformation:out
αC-helix conformation:in
G-rich loop angle (distance):54.4° (17.2Å)
G-rich loop rotation:32.8°
Quality Score:7.2
Resolution:2.5 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I8
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:ELLGEGAYAKVQGYAVKIIRVFREVETLYQCQKNILELIEFYLVFEKLQGGSILAHIQKFLHTKGIAHRDLKPENILCICDFDLG
Sequence structure:ELLGEGAYAKVQGYAVKIIRVFREVETLYQCQKNILELIEFYLVFEKLQGGSILAHIQKFLHTKGIAHRDLKPENILCICDFDLG