KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	PTK2 (FAK)
Family:	FAK
Group:	TK
Species:	HUMAN
IUPHAR/BPS ID:	2180
PDB:	3BZ3
sc-PDB:
KIDFamMap:	Search
Release date:	2008-04-01
PubMed:	18339875
Chain:	A
(Alternate) Model:	A
Orthosteric ligand:	YAM

More entries for 3BZ3
3BZ3	Alternative model:	B	Chain:	A

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	64.9° (19.1Å)
G-rich loop rotation:	93.4°
Quality Score:	8
Resolution:	2.2 Å
Missing Residues:	0
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets	Waters
front	FP-I FP-II	Cluster I1	Ligand No	Protein Yes

Pocket alignment
Uniprot sequence:	RCIGEGQFGDVHQVAIKTCKFLQEALTMRQFDPHIVKLIGVWIIMELCTLGELRSFLQVYLESKRFVHRDIAARNVLVLGDFGLS
Sequence structure:	RCIGEGQFGDVHQVAIKTCKFLQEALTMRQFDPHIVKLIGVWIIMELCTLGELRSFLQVYLESKRFVHRDIAARNVLVLGDFGLS

Ligand affinity
ChEMBL ID:	CHEMBL1084546
Bioaffinities:	115 records for 103 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	3-phosphoinositide dependent protein kinase-1	6	6	6	pKi	1
Homo sapiens	ALK tyrosine kinase receptor	6.7	6.7	6.7	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	6.4	6.4	6.4	pKi	1
Homo sapiens	BR serine/threonine-protein kinase 1	5.3	5.3	5.3	pKi	1
Homo sapiens	CaM kinase II delta	5.4	5.4	5.4	pKi	1
Homo sapiens	CaM kinase II gamma	5.6	5.6	5.6	pKi	1
Homo sapiens	CaM-kinase kinase beta	6.5	6.5	6.5	pKi	1
Homo sapiens	cAMP-dependent protein kinase alpha-catalytic subunit	6.8	6.8	6.8	pKi	1
Homo sapiens	Casein kinase I gamma 1	5.4	5.4	5.4	pKi	1
Homo sapiens	Casein kinase I gamma 2	5.4	5.4	5.4	pKi	1
Homo sapiens	Casein kinase II alpha	6	6	6	pKi	1
Homo sapiens	c-Jun N-terminal kinase 2	5.8	5.8	5.8	pKi	1
Homo sapiens	c-Jun N-terminal kinase 3	6.6	6.6	6.6	pKi	1
Homo sapiens	Cyclin-dependent kinase 1	7.2	7.2	7.2	pKi	1
Homo sapiens	Cyclin-dependent kinase 2	7.1	7.1	7.1	pKi	1
Homo sapiens	Cyclin-dependent kinase 5	7.8	7.8	7.8	pKi	1
Homo sapiens	Cyclin-dependent kinase 7	7.7	7.7	7.7	pKi	1
Homo sapiens	Cyclin-dependent kinase 9	7.2	7.2	7.2	pKi	1
Homo sapiens	Death-associated protein kinase 3	6	6	6	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.6	5.6	5.6	pKi	1
Homo sapiens	Dual specificity protein kinase CLK2	6.9	6.9	6.9	pKi	1
Homo sapiens	Dual specificity protein kinase CLK4	7.2	7.2	7.2	pKi	1
Homo sapiens	Ephrin type-A receptor 2	5.9	5.9	5.9	pKi	1
Homo sapiens	Fibroblast growth factor receptor 1	6.2	6.2	6.2	pKi	1
Homo sapiens	Fibroblast growth factor receptor 3	6.2	6.2	6.2	pKi	1
Homo sapiens	Focal adhesion kinase 1	8.8	8.8	9	pIC50	5
Homo sapiens	Focal adhesion kinase 1	9.2	9.2	9.2	pKi	1
Homo sapiens	Glycogen synthase kinase-3 alpha	7.1	7.1	7.1	pKi	1
Homo sapiens	Glycogen synthase kinase-3 beta	7	7	7	pKi	1
Homo sapiens	G protein-coupled receptor kinase 5	5.6	5.6	5.6	pKi	1
Homo sapiens	Hepatocyte growth factor receptor	6.6	6.6	6.6	pKi	1
Homo sapiens	Homeodomain-interacting protein kinase 2	6.7	6.7	6.7	pKi	1
Homo sapiens	Homeodomain-interacting protein kinase 4	6.3	6.3	6.3	pKi	1
Homo sapiens	Insulin-like growth factor I receptor	6.1	6.1	6.1	pKi	1
Homo sapiens	Insulin receptor	6.3	6.3	6.3	pKi	1
Homo sapiens	Interleukin-1 receptor-associated kinase 1	5.7	5.7	5.7	pKi	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	6.4	6.4	6.4	pKi	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	6.8	6.8	6.8	pKi	1
Homo sapiens	Leukocyte tyrosine kinase receptor	6.5	6.5	6.5	pKi	1
Homo sapiens	Macrophage-stimulating protein receptor	6.6	6.6	6.6	pKi	1
Homo sapiens	MAP kinase ERK2	7.2	7.2	7.2	pKi	1
Homo sapiens	MAP kinase p38 gamma	5.6	5.6	5.6	pKi	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	6.5	6.5	6.5	pKi	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	7.3	7.3	7.3	pKi	1
Homo sapiens	Maternal embryonic leucine zipper kinase	7.1	7.1	7.1	pKi	1
Homo sapiens	Misshapen-like kinase 1	6.2	6.2	6.2	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 10	6.7	6.7	6.7	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.8	5.8	5.8	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	6.2	6.2	6.2	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	6.9	6.9	6.9	pKi	1
Homo sapiens	Mixed lineage kinase 7	5.3	5.3	5.3	pKi	1
Homo sapiens	Nerve growth factor receptor Trk-A	6.4	6.4	6.4	pKi	1
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	7.4	7.4	7.4	pKi	1
Homo sapiens	Platelet-derived growth factor receptor beta	6	6	6	pKi	1
Homo sapiens	Protein kinase C delta	5.8	5.8	5.8	pKi	1
Homo sapiens	Protein kinase C gamma	5.2	5.2	5.2	pKi	1
Homo sapiens	Protein kinase C nu	5.9	5.9	5.9	pKi	1
Homo sapiens	Protein kinase C theta	6.4	6.4	6.4	pKi	1
Homo sapiens	Protein kinase N2	6.1	6.1	6.1	pKi	1
Homo sapiens	Protein tyrosine kinase 2 beta	7.9	7.9	7.9	pIC50	3
Homo sapiens	Protein tyrosine kinase 2 beta	8.5	8.5	8.5	pKi	1
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	7.9	7.9	7.9	pKi	1
Homo sapiens	Rho-associated protein kinase 1	5.7	5.7	5.7	pKi	1
Homo sapiens	Rho-associated protein kinase 2	5.7	5.7	5.7	pKi	1
Homo sapiens	Ribosomal protein S6 kinase 1	5.5	5.5	5.5	pKi	1
Homo sapiens	Ribosomal protein S6 kinase alpha 3	6.3	6.3	6.3	pKi	2
Homo sapiens	Serine/threonine-protein kinase 17A	5.9	5.9	5.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase 2	6.6	6.6	6.6	pKi	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	6.9	6.9	6.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	7.2	7.2	7.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase Chk2	6.1	6.1	6.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase c-TAK1	6.7	6.7	6.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase D2	5.9	5.9	5.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase MRCK-A	5.2	5.2	5.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase MST2	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK 1	5.4	5.4	5.4	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK 4	6.7	6.7	6.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase PLK4	6.2	6.2	6.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase PRKX	6.1	6.1	6.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase Sgk2	5.6	5.6	5.6	pKi	1
Homo sapiens	Serine/threonine-protein kinase SIK2	6.7	6.7	6.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase SRPK1	5.8	5.8	5.8	pKi	1
Homo sapiens	Serine/threonine-protein kinase TAO1	6.7	6.7	6.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase TBK1	5.7	5.7	5.7	pKi	1
Homo sapiens	Testis-specific serine/threonine-protein kinase 1	5.8	5.8	5.8	pKi	1
Homo sapiens	Tyrosine kinase non-receptor protein 2	5.9	5.9	5.9	pKi	1
Homo sapiens	Tyrosine-protein kinase BLK	6.4	6.4	6.4	pKi	1
Homo sapiens	Tyrosine-protein kinase BTK	5.7	5.7	5.7	pKi	1
Homo sapiens	Tyrosine-protein kinase CTK	7	7	7	pKi	1
Homo sapiens	Tyrosine-protein kinase FRK	7.4	7.4	7.4	pKi	1
Homo sapiens	Tyrosine-protein kinase FYN	5.7	5.7	5.7	pKi	1
Homo sapiens	Tyrosine-protein kinase HCK	5.5	5.5	5.5	pKi	1
Homo sapiens	Tyrosine-protein kinase ITK/TSK	7.1	7.1	7.1	pKi	1
Homo sapiens	Tyrosine-protein kinase JAK2	7.1	7.1	7.1	pKi	2
Homo sapiens	Tyrosine-protein kinase JAK3	6	6	6	pKi	2
Homo sapiens	Tyrosine-protein kinase LCK	6.3	6.3	6.3	pKi	1
Homo sapiens	Tyrosine-protein kinase Lyn	7	7	7	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	6.4	6.4	6.4	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor RET	6.5	6.5	6.5	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor UFO	6.7	6.7	6.7	pKi	1
Homo sapiens	Tyrosine-protein kinase SRC	6.3	6.3	6.3	pKi	1
Homo sapiens	Tyrosine-protein kinase TYK2	6.5	6.5	6.5	pKi	2
Homo sapiens	Vascular endothelial growth factor receptor 1	6.1	6.1	6.1	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 2	6.4	6.4	6.4	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 3	6.6	6.6	6.6	pKi	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 R
426

2 C
427

3 I
428

4 G
429

5 E
430

6 G
431

7 Q
432

8 F
433

9 G
434

10 D
435

11 V
436

12 H
437

13 Q
438

14 V
451

15 A
452

16 I
453

17 K
454

18 T
455

19 C
456

20 K
467

••

•

αC

b.l

21 F
468

22 L
469

23 Q
470

24 E
471

25 A
472

26 L
473

27 T
474

28 M
475

29 R
476

30 Q
477

31 F
478

32 D
479

33 P
481

34 H
482

35 I
483

36 V
484

37 K
485

38 L
486

39 I
487

40 G
488

•

hinge

linker

αD

αE

41 V
489

42 W
496

43 I
497

44 I
498

45 M
499

46 E
500

47 L
501

48 C
502

49 T
503

50 L
504

51 G
505

52 E
506

53 L
507

54 R
508

55 S
509

56 F
510

57 L
511

58 Q
512

59 V
513

60 Y
536

•

•••

•

αE

c.l

VII

VIII

61 L
537

62 E
538

63 S
539

64 K
540

65 R
541

66 F
542

67 V
543

68 H
544

69 R
545

70 D
546

71 I
547

72 A
548

73 A
549

74 R
550

75 N
551

76 V
552

77 L
553

78 V
554

79 L
562

80 G
563

•

DFG

a.l

81 D
564

82 F
565

83 G
566

84 L
567

85 S
568

•

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: