Pim-1 proto-oncogene, serine/threonine kinase
Kinase structure
Kinase:PIM1
Family:PIM
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2158
PDB:1XQZ
sc-PDB:
KIDFamMap:Search
Release date:2004-11-09
PubMed: 15525646
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):51.4° (15.8Å)
G-rich loop rotation:39.5°
Quality Score:8
Resolution:2.1 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I4
I10
Ligand
No
No
Protein
Yes
Yes

Pocket alignment
Uniprot sequence:PLLGSGGFGSVYSVAIKHVRVPMEVVLLKKVSSGVIRLLDWVLILERPEVQDLFDFITEHCHNCGVLHRDIKDENILILIDFGSG
Sequence structure:PLLGSGGFGSVYSVAIKHVRVPMEVVLLKKVSSGVIRLLDWVLILERPEVQDLFDFITEHCHNCGVLHRDIKDENILILIDFGSG