Version: 3.2
Updated: 29-Oct-2025
Pim-1 proto-oncogene, serine/threonine kinase
Kinase structure
Kinase:PIM1
Family:PIM
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2158
PDB:3JYA
sc-PDB:
KIDFamMap:Search
Release date:2009-11-10
Chain:A
(Alternate) Model:A
Orthosteric ligand:LWG
2D structure of the orthosteric ligand
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):51.1° (15.8Å)
G-rich loop rotation:40.7°
Quality Score:8
Resolution:2.1 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
PocketsSubpockets
front

Pocket alignment
Uniprot sequence:PLLGSGGFGSVYSVAIKHVRVPMEVVLLKKVSSGVIRLLDWVLILERPEVQDLFDFITEHCHNCGVLHRDIKDENILILIDFGSG
Sequence structure:PLLGSGGFGSVYSVAIKHVRVPMEVVLLKKVSSGVIRLLDWVLILERPEVQDLFDFITEHCHNCGVLHRDIKDENILILIDFGSG

Ligand affinity
ChEMBL ID:CHEMBL583144
Bioaffinities: 70 records for 56 kinases
Species Kinase (ChEMBL naming) Median Min Max Type Records
Homo sapiensALK tyrosine kinase receptor5.95.95.9pKi1
Homo sapiensCaM kinase II beta5.15.15.1pKi1
Homo sapiensCaM kinase II delta5.35.35.3pKi1
Homo sapiensCaM kinase II gamma5.45.45.4pKi1
Homo sapiensCasein kinase I delta5.65.65.6pKi1
Homo sapiensCasein kinase II alpha6.96.96.9pKi1
Homo sapiensCell division cycle 7-related protein kinase6.96.96.9pKi1
Homo sapienscGMP-dependent protein kinase 1 beta5.95.95.9pKi1
Homo sapienscGMP-dependent protein kinase 25.85.85.8pKi1
Homo sapiensCyclin-dependent kinase 15.15.15.1pKi1
Homo sapiensCyclin-dependent kinase 25.35.35.3pKi1
Homo sapiensDeath-associated protein kinase 36.86.86.8pKi1
Homo sapiensDual specificity protein kinase CLK2666pKi1
Homo sapiensDual specificity protein kinase CLK4777.1pKi2
Homo sapiensDual-specificity tyrosine-phosphorylation regulated kinase 1A777pKi1
Homo sapiensDual-specificity tyrosine-phosphorylation regulated kinase 3666pKi1
Homo sapiensGlycogen synthase kinase-3 alpha666pKi1
Homo sapiensGlycogen synthase kinase-3 beta5.45.45.4pKi1
Homo sapiensHomeodomain-interacting protein kinase 26.76.76.7pKi1
Homo sapiensHomeodomain-interacting protein kinase 45.35.35.3pKi1
Homo sapiensInhibitor of nuclear factor kappa B kinase beta subunit5.65.65.6pKi1
Homo sapiensInsulin-like growth factor I receptor666pKi1
Homo sapiensMAP kinase-activated protein kinase 5666pKi1
Homo sapiensMAP kinase signal-integrating kinase 25.25.25.2pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 46.16.16.1pKi2
Homo sapiensNT-3 growth factor receptor6.16.16.1pKi2
Homo sapiensPDZ-binding kinase6.56.56.5pKi2
Homo sapiensPhosphorylase kinase gamma subunit 25.55.55.5pKi1
Homo sapiensProtein kinase C nu5.75.75.7pKi1
Homo sapiensProtein kinase N25.85.85.8pKi1
Homo sapiensProto-oncogene tyrosine-protein kinase ROS5.95.95.9pKi1
Homo sapiensRho-associated protein kinase 15.45.45.4pKi1
Homo sapiensRho-associated protein kinase 2666pKi1
Homo sapiensRibosomal protein S6 kinase 16.16.16.1pKi2
Homo sapiensRibosomal protein S6 kinase alpha 56.16.16.1pKi4
Homo sapiensSerine/threonine-protein kinase 17A6.36.36.3pKi1
Homo sapiensSerine/threonine-protein kinase Aurora-A5.85.85.8pKi1
Homo sapiensSerine/threonine-protein kinase D25.55.55.5pKi1
Homo sapiensSerine/threonine-protein kinase MRCK-A5.35.35.3pKi1
Homo sapiensSerine/threonine-protein kinase PIM16.96.96.9pKi2
Homo sapiensSerine/threonine-protein kinase PIM26.86.86.8pKi2
Homo sapiensSerine/threonine-protein kinase PIM37.97.98pKi2
Homo sapiensSerine/threonine-protein kinase PLK35.15.15.1pKi1
Homo sapiensSerine/threonine-protein kinase PRKX6.26.26.2pKi2
Homo sapiensSerine/threonine-protein kinase SRPK15.25.25.2pKi1
Homo sapiensSerine/threonine-protein kinase TAO15.75.75.7pKi1
Homo sapiensTestis-specific serine/threonine-protein kinase 25.95.95.9pKi1
Homo sapiensTyrosine-protein kinase BTK6.26.26.2pKi2
Homo sapiensTyrosine-protein kinase CTK5.75.75.7pKi1
Homo sapiensTyrosine-protein kinase FES666pKi1
Homo sapiensTyrosine-protein kinase FRK5.75.75.7pKi1
Homo sapiensTyrosine-protein kinase receptor RET5.95.95.9pKi1
Homo sapiensTyrosine-protein kinase receptor TYRO3666pKi1
Homo sapiensTyrosine-protein kinase receptor UFO666pKi1
Homo sapiensTyrosine-protein kinase Srms5.85.85.8pKi1
Homo sapiensTyrosine-protein kinase SYK6.56.56.5pKi2


Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
I g.l II III αC
1 P
42		2 L
43		3 L
44		4 G
45		5 S
46		6 G
47		7 G
48		8 F
49		9 G
50		10 S
51		11 V
52		12 Y
53		13 S
54		14 V
64		15 A
65		16 I
66		17 K
67		18 H
68		19 V
69		20 R
85
••••••
αC b.l IV
21 V
86		22 P
87		23 M
88		24 E
89		25 V
90		26 V
91		27 L
92		28 L
93		29 K
94		30 K
95		31 V
96		32 S
97		33 S
101		34 G
102		35 V
103		36 I
104		37 R
105		38 L
106		39 L
107		40 D
108
•
IV V GK hinge linker αD αE
41 W
109		42 V
117		43 L
118		44 I
119		45 L
120		46 E
121		47 R
122		48 P
123		49 E
124		50 V
126		51 Q
127		52 D
128		53 L
129		54 F
130		55 D
131		56 F
132		57 I
133		58 T
134		59 E
135		60 H
157
•••••
αE VI c.l VII VIII x
61 C
158		62 H
159		63 N
160		64 C
161		65 G
162		66 V
163		67 L
164		68 H
165		69 R
166		70 D
167		71 I
168		72 K
169		73 D
170		74 E
171		75 N
172		76 I
173		77 L
174		78 I
175		79 L
184		80 I
185
••
DFG a.l
81 D
186		82 F
187		83 G
188		84 S
189		85 G
190

Interaction pattern search
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