Pim-1 proto-oncogene, serine/threonine kinase
Kinase structure
Kinase:PIM1
Family:PIM
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2158
PDB:4JX3
sc-PDB:
KIDFamMap:Search
Release date:2013-08-28
PubMed: 23936194
Chain:A
Click to open a 3D viewer
The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):52.1° (15.9Å)
G-rich loop rotation:43.7°
Quality Score:8
Resolution:2.5 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I4
I5
I10
Ligand
No
No
No
No
Protein
Yes
Yes
No
Yes

Pocket alignment
Uniprot sequence:PLLGSGGFGSVYSVAIKHVRVPMEVVLLKKVSSGVIRLLDWVLILERPEVQDLFDFITEHCHNCGVLHRDIKDENILILIDFGSG
Sequence structure:PLLGSGGFGSVYSVAIKHVRVPMEVVLLKKVSSGVIRLLDWVLILERPEVQDLFDFITEHCHNCGVLHRDIKDENILILIDFGSG