Version: 3.2
Updated: 05-Nov-2025
Microtubule affinity regulating kinase 1
Kinase structure
Kinase:MARK1
Family:CAMKL
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2097
PDB:2HAK
sc-PDB:
KIDFamMap:Search
Release date:2006-07-11
PubMed: 16472737
Chain:E
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The orthosteric binding pocket


More entries for 2HAK
2HAKChain: A
2HAKChain: B
2HAKChain: C
2HAKChain: D
2HAKChain: F
2HAKChain: G
2HAKChain: H


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):62.2° (18.5Å)
G-rich loop rotation:56.8°
Quality Score:7.6
Resolution:2.6 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I5
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:KTIGKGNFAKVKLVAVKIIKLFREVRIMKILNPNIVKLFEVYLVMEYASGGEVFDYLVAYCHQKYIVHRDLKAENLLLIADFGFS
Sequence structure:KTIGKGNFAKVKLVAVKIIKLFREVRIMKILNPNIVKLFEVYLVMEYASGGEVFDYLVAYCHQKYIVHRDLKAENLLLIADFGFS