PDB-code
| Kinase structure | |
| Kinase: | PRKCB (PKCb) |
| Family: | PKC |
| Group: | AGC |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1483 |
| PDB: | 2I0E |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2006-11-14 |
| PubMed: | 17115692 |
| Chain: | A |
| Orthosteric ligand: | PDS |
 | |
| More entries for 2I0E | |||
| 2I0E | Chain: | B | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 55.1° (17Å) |
| G-rich loop rotation: | 41.8° |
| Quality Score: | 8 |
| Resolution: | 2.6 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | FP-I | Cluster I4 I5 | Ligand No Yes | Protein Yes Yes |
| Pocket alignment | |
| Uniprot sequence: | MVLGKGSFGKVMLYAVKILCTMVEKRVLALPGPFLTQLHSCYFVMEYVNGGDLMYHIQQFLQSKGIIYRDLKLDNVMLIADFGMC |
| Sequence structure: | MVLGKGSFGKVMLYAVKILCTMVEKRVLALPGPFLTQLHSCYFVMEYVNGGDLMYHIQQFLQSKGIIYRDLKLDNVMLIADFGMC |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 M 346 | 2 V 347 | 3 L 348 | 4 G 349 | 5 K 350 | 6 G 351 | 7 S 352 | 8 F 353 | 9 G 354 | 10 K 355 | 11 V 356 | 12 M 357 | 13 L 358 | 14 Y 368 | 15 A 369 | 16 V 370 | 17 K 371 | 18 I 372 | 19 L 373 | 20 C 386 |
| • | • | •• | • | • | • | ||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 T 387 | 22 M 388 | 23 V 389 | 24 E 390 | 25 K 391 | 26 R 392 | 27 V 393 | 28 L 394 | 29 A 395 | 30 L 396 | 31 P 397 | 32 G 398 | 33 P 401 | 34 F 402 | 35 L 403 | 36 T 404 | 37 Q 405 | 38 L 406 | 39 H 407 | 40 S 408 |
| • | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 C 409 | 42 Y 417 | 43 F 418 | 44 V 419 | 45 M 420 | 46 E 421 | 47 Y 422 | 48 V 423 | 49 N 424 | 50 G 425 | 51 G 426 | 52 D 427 | 53 L 428 | 54 M 429 | 55 Y 430 | 56 H 431 | 57 I 432 | 58 Q 433 | 59 Q 434 | 60 F 456 |
| • | • | • | •• | ||||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 457 | 62 Q 458 | 63 S 459 | 64 K 460 | 65 G 461 | 66 I 462 | 67 I 463 | 68 Y 464 | 69 R 465 | 70 D 466 | 71 L 467 | 72 K 468 | 73 L 469 | 74 D 470 | 75 N 471 | 76 V 472 | 77 M 473 | 78 L 474 | 79 I 482 | 80 A 483 |
| ••• | • | • | • | ||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 484 | 82 F 485 | 83 G 486 | 84 M 487 | 85 C 488 | |||||||||||||||
| • | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
