KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	MAPK11 (p38b)
Family:	MAPK
Group:	CMGC
Species:	HUMAN
IUPHAR/BPS ID:	1500
PDB:	3GP0
sc-PDB:
KIDFamMap:	Search
Release date:	2009-04-07
Chain:	A
(Alternate) Model:	A
Orthosteric ligand:	NIL

More entries for 3GP0
3GP0	Alternative model:	B	Chain:	A

Structural information
DFG conformation:	out
αC-helix conformation:	in
G-rich loop angle (distance):	-
G-rich loop rotation:	-
Quality Score:	6.4
Resolution:	1.9 Å
Missing Residues:	7
Missing Atoms:	8

Ligand binding mode
Pockets	Subpockets	Waters
front gate back	BP-I-A BP-I-B BP-II-out BP-III BP-V	Cluster I3 O1	Ligand No Yes	Protein Yes No

Pocket alignment
Uniprot sequence:	RPVGSGAYGSVCSVAVKKLRTYRELRLLKHLKENVIGLLDVYLVTTLMG-ADLNNIVKCYIHSAGIIHRDLKPSNVAVILDFGLA
Sequence structure:	RPVGS_____VCSVAVKKLRTYRELRLLKHLKENVIGLLDVYLVTTLMG_ADLNNIVKCYIHSAGIIHRDLKPSNVAVILDFG__

Ligand affinity
ChEMBL ID:	CHEMBL255863
Bioaffinities:	113 records for 53 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Plasmodium falciparum (isolate 3D7)	Calcium-dependent protein kinase 1	6.1	6.1	6.1	pKd	1
Homo sapiens	c-Jun N-terminal kinase 1	6.4	6.4	6.4	pKd	1
Homo sapiens	c-Jun N-terminal kinase 2	5.2	5.2	5.2	pKd	1
Homo sapiens	c-Jun N-terminal kinase 3	5.7	5.7	5.7	pKd	1
Homo sapiens	Discoidin domain-containing receptor 2	7.8	7	8.7	pIC50	5
Homo sapiens	Discoidin domain-containing receptor 2	7.5	7.1	8.2	pKd	4
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	6.7	6.7	6.7	pKd	1
Homo sapiens	Dual specificity protein kinase CLK4	5.2	5.2	5.2	pKd	1
Homo sapiens	Dual specificty protein kinase CLK1	5.7	5.7	5.7	pKd	2
Homo sapiens	Ephrin type-A receptor 1	6.2	6.2	6.2	pKd	1
Homo sapiens	Ephrin type-A receptor 2	6.6	6.6	6.6	pKd	1
Homo sapiens	Ephrin type-A receptor 3	7	7	7	pKd	1
Homo sapiens	Ephrin type-A receptor 4	6.5	6.5	6.5	pKd	1
Homo sapiens	Ephrin type-A receptor 5	5.7	5.7	5.7	pKd	1
Homo sapiens	Ephrin type-A receptor 6	6.2	6.2	6.2	pKd	1
Homo sapiens	Ephrin type-A receptor 8	7.4	7.4	7.4	pKd	1
Homo sapiens	Ephrin type-B receptor 1	5.9	5.9	5.9	pKd	1
Homo sapiens	Ephrin type-B receptor 2	6.2	6.2	6.2	pKd	1
Homo sapiens	Ephrin type-B receptor 3	6	6	6	pKd	1
Homo sapiens	Ephrin type-B receptor 4	6.1	6.1	6.1	pKd	1
Homo sapiens	Epithelial discoidin domain-containing receptor 1	7.5	7.4	8.4	pIC50	3
Homo sapiens	Epithelial discoidin domain-containing receptor 1	9	9	9	pKd	1
Homo sapiens	Macrophage colony stimulating factor receptor	6.2	6.2	6.2	pIC50	1
Homo sapiens	Macrophage colony stimulating factor receptor	7.4	7.4	7.4	pKd	1
Homo sapiens	MAP kinase p38 alpha	6.3	6.3	6.3	pKd	2
Homo sapiens	MAP kinase p38 beta	7.4	7.4	7.4	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	6.1	6.1	6.1	pKd	1
Homo sapiens	Mixed lineage kinase 7	8	8	8	pKd	1
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	6.3	6.3	6.3	pKd	1
Homo sapiens	NT-3 growth factor receptor	6.2	6.2	6.2	pKd	1
Homo sapiens	Platelet-derived growth factor receptor alpha	7.2	7.2	7.2	pIC50	1
Homo sapiens	Platelet-derived growth factor receptor alpha	6.8	6.8	7.1	pKd	2
Homo sapiens	Platelet-derived growth factor receptor beta	7.2	7.2	7.2	pIC50	2
Homo sapiens	Platelet-derived growth factor receptor beta	7.1	7.1	7.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase 10	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase B-raf	5.8	5.8	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase MRCK beta	6	6	6	pKd	1
Homo sapiens	Serine/threonine-protein kinase RAF	6	6	6	pIC50	1
Homo sapiens	Serine/threonine-protein kinase RAF	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO1	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO3	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase TNNI3K	6.4	6.4	6.4	pKd	1
Homo sapiens	Stem cell growth factor receptor	6.8	6.7	7.8	pIC50	3
Homo sapiens	Stem cell growth factor receptor	7.3	6.1	7.8	pKd	9
Homo sapiens	Tyrosine-protein kinase ABL	7.5	6.2	7.9	pIC50	10
Homo sapiens	Tyrosine-protein kinase ABL	7.9	6.2	8.4	pKd	15
Homo sapiens	Tyrosine-protein kinase ABL2	7.6	7.6	7.6	pKd	1
Homo sapiens	Tyrosine-protein kinase BLK	6.3	6.3	6.3	pKd	1
Homo sapiens	Tyrosine-protein kinase CSK	5.6	5.6	5.6	pKd	1
Homo sapiens	Tyrosine-protein kinase FGR	6.5	6.5	6.5	pKd	1
Homo sapiens	Tyrosine-protein kinase FRK	7.1	7.1	7.1	pKd	1
Homo sapiens	Tyrosine-protein kinase FYN	5.8	5.8	5.8	pKd	1
Homo sapiens	Tyrosine-protein kinase HCK	6.4	6.4	6.4	pKd	1
Homo sapiens	Tyrosine-protein kinase LCK	7	7	7	pIC50	1
Homo sapiens	Tyrosine-protein kinase LCK	7.3	7.3	7.3	pKd	1
Homo sapiens	Tyrosine-protein kinase Lyn	5.9	5.9	5.9	pIC50	1
Homo sapiens	Tyrosine-protein kinase Lyn	7	7	7	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	5	5	5	pIC50	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	4.4	4.4	4.4	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor RET	6	6	6.1	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	6	6	6	pKd	1
Homo sapiens	Tyrosine-protein kinase SRC	5.7	5.7	5.7	pKd	1
Homo sapiens	Tyrosine-protein kinase TIE-2	6	6	6	pKd	1
Homo sapiens	Tyrosine-protein kinase YES	6	6	6	pKd	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 R
28

2 P
29

3 V
30

4 G
31

5 S
37

6 _
_

7 _
_

8 _
_

9 _
_

10 _
_

11 V
38

12 C
39

13 S
40

14 V
50

15 A
51

16 V
52

17 K
53

18 K
54

19 L
55

20 R
67

•

αC

b.l

21 T
68

22 Y
69

23 R
70

24 E
71

25 L
72

26 R
73

27 L
74

28 L
75

29 K
76

30 H
77

31 L
78

32 K
79

33 E
81

34 N
82

35 V
83

36 I
84

37 G
85

38 L
86

39 L
87

40 D
88

•

••

•

hinge

linker

αD

αE

41 V
89

42 Y
103

43 L
104

44 V
105

45 T
106

46 T
107

47 L
108

48 M
109

49 G
110

50 _
_

51 A
111

52 D
112

53 L
113

54 N
114

55 N
115

56 I
116

57 V
117

58 K
118

59 C
119

60 Y
140

•

••

•

••

•

αE

c.l

VII

VIII

61 I
141

62 H
142

63 S
143

64 A
144

65 G
145

66 I
146

67 I
147

68 H
148

69 R
149

70 D
150

71 L
151

72 K
152

73 P
153

74 S
154

75 N
155

76 V
156

77 A
157

78 V
158

79 I
166

80 L
167

•

DFG

a.l

81 D
168

82 F
169

83 G
170

84 _
_

85 _
_

••

Interaction pattern search

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