Mixed lineage kinase domain-like
Kinase structure
Kinase:MLKL
Family:TKL-Unique
Group:TKL
Species:HUMAN
PDB:4MWI
sc-PDB:
KIDFamMap:Search
Release date:2013-12-04
PubMed: 24219132
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 4MWI
4MWIAlternative model: AChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):50.3° (15.5Å)
G-rich loop rotation:57.9°
Quality Score:8
Resolution:1.7 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I3
I5
I8
I10
I11
O2
Ligand
No
No
No
No
No
No
Protein
No
Yes
Yes
No
Yes
Yes

Allosteric Ligand
Allosteric ligand:PXN
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:ILLRENEVSTLYKVAIKVFTFNKEIKTMKKFEPNILRIFGISIVMEYCELGTLRELLDRHHSEAPELHGKIRSSNFLVLAGFELR
Sequence structure:ILLRENEVSTLYKVAIKVFTFNKEIKTMKKFEPNILRIFGISIVMEYCELGTLRELLDRHHSEAPELHGKIRSSNFLVLAGFELR