Neurotrophic tyrosine kinase, receptor, type 1
Kinase structure
Kinase:NTRK1 (TRKA)
Family:Trk
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1817
PDB:4F0I
sc-PDB:
KIDFamMap:Search
Release date:2012-09-05
PubMed: 22902478
Chain:B
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The orthosteric binding pocket


More entries for 4F0I
4F0IChain: A


Structural information
DFG conformation:out
αC-helix conformation:in
G-rich loop angle (distance):60.8° (18.9Å)
G-rich loop rotation:48.8°
Quality Score:7.2
Resolution:2.3 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I4
I8
I9
Ligand
No
No
No
Protein
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:WELGEGAFGKVFLVAVKALDFQREAELLTMLQQHIVRFFGVLMVFEYMRHGDLNRFLRSYLAGLHFVHRDLATRNCLVIGDFGMS
Sequence structure:WELGEGAFGKVFLVAVKALDFQREAELLTMLQQHIVRFFGVLMVFEYMRHGDLNRFLRSYLAGLHFVHRDLATRNCLVIGDFGMS