PDB-code
| Kinase structure | |
| Kinase: | PLK3 |
| Family: | PLK |
| Group: | Other |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2170 |
| PDB: | 4B6L |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2013-08-21 |
| Chain: | A |
| Orthosteric ligand: | 9ZP |
 | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 56.3° (16.4Å) |
| G-rich loop rotation: | 54.2° |
| Quality Score: | 8 |
| Resolution: | 1.9 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | Cluster I2 I4 I5 I10 I11 | Ligand No No Yes No Yes | Protein Yes Yes Yes Yes Yes | |
| Pocket alignment | |
| Uniprot sequence: | RLLGKGGFARCYEYAVKVIKILNEIELHRDLQRHIVRFSHHYIFLELCSRKSLAHIWKAYLHQRGILHRDLKLGNFFIVGDFGLA |
| Sequence structure: | RLLGKGGFARCYEYAVKVIKILNEIELHRDLQRHIVRFSHHYIFLELCSRKSLAHIWKAYLHQRGILHRDLKLGNFFIVGDFGLA |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 R 66 | 2 L 67 | 3 L 68 | 4 G 69 | 5 K 70 | 6 G 71 | 7 G 72 | 8 F 73 | 9 A 74 | 10 R 75 | 11 C 76 | 12 Y 77 | 13 E 78 | 14 Y 88 | 15 A 89 | 16 V 90 | 17 K 91 | 18 V 92 | 19 I 93 | 20 K 106 |
| • | • | •• | • | • | • | • | |||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 I 107 | 22 L 108 | 23 N 109 | 24 E 110 | 25 I 111 | 26 E 112 | 27 L 113 | 28 H 114 | 29 R 115 | 30 D 116 | 31 L 117 | 32 Q 118 | 33 R 120 | 34 H 121 | 35 I 122 | 36 V 123 | 37 R 124 | 38 F 125 | 39 S 126 | 40 H 127 |
| • | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 H 128 | 42 Y 136 | 43 I 137 | 44 F 138 | 45 L 139 | 46 E 140 | 47 L 141 | 48 C 142 | 49 S 143 | 50 R 144 | 51 K 145 | 52 S 146 | 53 L 147 | 54 A 148 | 55 H 149 | 56 I 150 | 57 W 151 | 58 K 152 | 59 A 153 | 60 Y 175 |
| • | • | • | ••• | • | • | •• | |||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 176 | 62 H 177 | 63 Q 178 | 64 R 179 | 65 G 180 | 66 I 181 | 67 L 182 | 68 H 183 | 69 R 184 | 70 D 185 | 71 L 186 | 72 K 187 | 73 L 188 | 74 G 189 | 75 N 190 | 76 F 191 | 77 F 192 | 78 I 193 | 79 V 201 | 80 G 202 |
| •• | |||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 203 | 82 F 204 | 83 G 205 | 84 L 206 | 85 A 207 | |||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
