PDB-code
| Kinase structure | |
| Kinase: | FLT1 |
| Family: | VEGFR |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1812 |
| PDB: | 3HNG |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2009-06-30 |
| Chain: | A |
| (Alternate) Model: | A |
| Orthosteric ligand: | 8ST |
 | |
| More entries for 3HNG | |||||
| 3HNG | Alternative model: | B | Chain: | A | |
| Structural information | |
| DFG conformation: | out |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 59.6° (18.4Å) |
| G-rich loop rotation: | 39° |
| Quality Score: | 7.6 |
| Resolution: | 2.7 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | |||
| front gate back | BP-I-B BP-II-out | |||
| Pocket alignment | |
| Uniprot sequence: | KSLGRGAFGKVVQVAVKMLALMTELKILTHIGLNVVNLLGAMVIVEYCKYGNLSNYLKSFLSSRKCIHRDLAARNILLICDFGLA |
| Sequence structure: | KSLGRGAFGKVVQVAVKMLALMTELKILTHIGLNVVNLLGAMVIVEYCKYGNLSNYLKSFLSSRKCIHRDLAARNILLICDFGLA |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL101683 |
| Bioaffinities: | 7 records for 5 kinases |
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | Epidermal growth factor receptor erbB1 | 5.1 | 5.1 | 5.1 | pIC50 | 1 |
| Homo sapiens | Stem cell growth factor receptor | 6.6 | 6.6 | 6.6 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 5.2 | 5.2 | 5.2 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 6.8 | 6.8 | 6.8 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 7.7 | 7.7 | 7.7 | pIC50 | 2 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 7.8 | 7.8 | 7.8 | pKi | 1 |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 K 831 | 2 S 832 | 3 L 833 | 4 G 834 | 5 R 835 | 6 G 836 | 7 A 837 | 8 F 838 | 9 G 839 | 10 K 840 | 11 V 841 | 12 V 842 | 13 Q 843 | 14 V 858 | 15 A 859 | 16 V 860 | 17 K 861 | 18 M 862 | 19 L 863 | 20 A 874 |
| • | • | • | • | • | |||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 L 875 | 22 M 876 | 23 T 877 | 24 E 878 | 25 L 879 | 26 K 880 | 27 I 881 | 28 L 882 | 29 T 883 | 30 H 884 | 31 I 885 | 32 G 886 | 33 L 889 | 34 N 890 | 35 V 891 | 36 V 892 | 37 N 893 | 38 L 894 | 39 L 895 | 40 G 896 |
| •• | • | • | • | ||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 A 897 | 42 M 906 | 43 V 907 | 44 I 908 | 45 V 909 | 46 E 910 | 47 Y 911 | 48 C 912 | 49 K 913 | 50 Y 914 | 51 G 915 | 52 N 916 | 53 L 917 | 54 S 918 | 55 N 919 | 56 Y 920 | 57 L 921 | 58 K 922 | 59 S 923 | 60 F 1012 |
| • | • | • | •• | •• | |||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 1013 | 62 S 1014 | 63 S 1015 | 64 R 1016 | 65 K 1017 | 66 C 1018 | 67 I 1019 | 68 H 1020 | 69 R 1021 | 70 D 1022 | 71 L 1023 | 72 A 1024 | 73 A 1025 | 74 R 1026 | 75 N 1027 | 76 I 1028 | 77 L 1029 | 78 L 1030 | 79 I 1038 | 80 C 1039 |
| • | • | • | • | • | |||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 1040 | 82 F 1041 | 83 G 1042 | 84 L 1043 | 85 A 1044 | |||||||||||||||
| •• | • | ||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
