PDB-code
| Kinase structure | |
| Kinase: | CAMKK2 (CaMKK2) |
| Family: | CAMKK |
| Group: | Other |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1957 |
| PDB: | 2ZV2 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2009-11-03 |
| PubMed: | 21504895 |
| Chain: | A |
| Orthosteric ligand: | 609 |
 | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | - |
| G-rich loop rotation: | - |
| Quality Score: | 7.2 |
| Resolution: | 2.4 Å |
| Missing Residues: | 2 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | Cluster I4 | Ligand Yes | Protein Yes | |
| Pocket alignment | |
| Uniprot sequence: | DEIGKGSYGVVKLYAMKVLQVYQEIAILKKLDPNVVKLVEVYMVFELVNQGPVMEVPTLYLHYQKIIHRDIKPSNLLVIADFGVS |
| Sequence structure: | DEIGK__YGVVKLYAMKVLQVYQEIAILKKLDPNVVKLVEVYMVFELVNQGPVMEVPTLYLHYQKIIHRDIKPSNLLVIADFGVS |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL1182777 |
| Bioaffinities: | No (p)Ki/(p)IC50/(p)EC50 values for kinases found (confidence ≥ 8). |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 D 170 | 2 E 171 | 3 I 172 | 4 G 173 | 5 K 174 | 6 _ _ | 7 _ _ | 8 Y 177 | 9 G 178 | 10 V 179 | 11 V 180 | 12 K 181 | 13 L 182 | 14 Y 192 | 15 A 193 | 16 M 194 | 17 K 195 | 18 V 196 | 19 L 197 | 20 Q 233 |
| • | • | • | •• | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 V 234 | 22 Y 235 | 23 Q 236 | 24 E 237 | 25 I 238 | 26 A 239 | 27 I 240 | 28 L 241 | 29 K 242 | 30 K 243 | 31 L 244 | 32 D 245 | 33 P 247 | 34 N 248 | 35 V 249 | 36 V 250 | 37 K 251 | 38 L 252 | 39 V 253 | 40 E 254 |
| • | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 255 | 42 Y 265 | 43 M 266 | 44 V 267 | 45 F 268 | 46 E 269 | 47 L 270 | 48 V 271 | 49 N 272 | 50 Q 273 | 51 G 274 | 52 P 275 | 53 V 276 | 54 M 277 | 55 E 278 | 56 V 279 | 57 P 280 | 58 T 281 | 59 L 282 | 60 Y 303 |
| •• | • | •• | • | • | • | ||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 304 | 62 H 305 | 63 Y 306 | 64 Q 307 | 65 K 308 | 66 I 309 | 67 I 310 | 68 H 311 | 69 R 312 | 70 D 313 | 71 I 314 | 72 K 315 | 73 P 316 | 74 S 317 | 75 N 318 | 76 L 319 | 77 L 320 | 78 V 321 | 79 I 329 | 80 A 330 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 331 | 82 F 332 | 83 G 333 | 84 V 334 | 85 S 335 | |||||||||||||||
| •• | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
