KLIFS - the kinase structures database

Version: 3.2
Updated: 01-Nov-2025

Kinase structure
Kinase:	AURKB (AurB)
Family:	Aur
Group:	Other
Species:	HUMAN
IUPHAR/BPS ID:	1937
PDB:	4AF3
sc-PDB:
KIDFamMap:	Search
Release date:	2012-04-11
PubMed:	22920039
Chain:	A
Orthosteric ligand:	VX6

Structural information
DFG conformation:	out-like
αC-helix conformation:	in
G-rich loop angle (distance):	63.4° (18.2Å)
G-rich loop rotation:	34.5°
Quality Score:	7
Resolution:	2.75 Å
Missing Residues:	2
Missing Atoms:	18

Ligand binding mode
Pockets	Subpockets
front

Pocket alignment
Uniprot sequence:	RPLGKGKFGNVYLVALKVLQLRREIEIQAHLHPNILRLYNYYLILEYAPRGELYKELQKYCHGKKVIHRDIKPENLLLIADFGWS
Sequence structure:	RPLGKGKFGNVYLVALKVLQLRREIEIQAHLHPNILRLYNYYLILEYAPRGELYKELQKYCHGKKVIHRDIKPENLLLIADFG__

Ligand affinity
ChEMBL ID:	CHEMBL572878
Bioaffinities:	576 records for 211 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	3-phosphoinositide dependent protein kinase-1	5.6	5.6	5.6	pKi	1
Homo sapiens	Activin receptor type-1	5.7	5.7	5.7	pKd	2
Homo sapiens	Activin receptor type-1	5.9	5.9	5.9	pKi	1
Homo sapiens	Adaptor-associated kinase	6.5	6.5	6.5	pKd	2
Homo sapiens	ALK tyrosine kinase receptor	5.5	5.5	5.5	pKd	2
Homo sapiens	ALK tyrosine kinase receptor	5.6	5.6	5.6	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	6	6	6	pKd	2
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	5.6	5.6	5.6	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-2 subunit	6.5	6.5	6.5	pKd	2
Homo sapiens	Ankyrin repeat and protein kinase domain-containing protein 1	5.3	5.3	5.3	pKd	2
Xenopus laevis	Aurora kinase B-A	7.7	7.7	7.7	pIC50	1
Homo sapiens	BMP-2-inducible protein kinase	7.2	7.2	7.2	pKd	2
Homo sapiens	Bone morphogenetic protein receptor type-1B	6	6	6	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-2	5.2	5.2	5.2	pKd	2
Homo sapiens	BR serine/threonine-protein kinase 1	5.1	5.1	5.1	pKd	1
Homo sapiens	BR serine/threonine-protein kinase 1	5.2	5.2	5.2	pKi	1
Homo sapiens	CaM kinase I alpha	5.2	5.2	5.2	pKd	1
Homo sapiens	CaM kinase I delta	5.3	5.3	5.3	pKd	2
Homo sapiens	CaM kinase I gamma	5.2	5.2	5.2	pKd	1
Homo sapiens	CaM-kinase kinase alpha	5.3	5.3	5.3	pKd	1
Homo sapiens	Casein kinase II alpha	6.4	6.4	6.4	pKd	1
Homo sapiens	Casein kinase II alpha (prime)	6.4	6.4	6.4	pKd	1
Homo sapiens	Cell division cycle 2-like protein kinase 6	6.7	6.7	6.7	pKi	1
Homo sapiens	c-Jun N-terminal kinase 3	5.6	5.6	5.6	pKd	2
Homo sapiens	c-Jun N-terminal kinase 3	5.7	5.7	5.7	pKi	1
Homo sapiens	Cyclin-dependent kinase-like 2	7.3	7.3	7.3	pKd	1
Homo sapiens	Cyclin-dependent kinase-like 3	6.5	6.5	6.5	pKd	1
Homo sapiens	Cyclin-dependent kinase-like 5	5.6	5.6	5.6	pKd	1
Homo sapiens	Death-associated protein kinase 3	5	5	6.7	pKd	2
Homo sapiens	Discoidin domain-containing receptor 2	6.6	6.6	7.8	pIC50	2
Homo sapiens	Discoidin domain-containing receptor 2	6.6	6.6	6.6	pKd	3
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	5.8	5.8	5.8	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	5.9	5.9	5.9	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.7	5.7	5.7	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.7	5.7	5.7	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	6.6	6.6	6.6	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	5.6	5.6	5.6	pKd	2
Homo sapiens	Dual specificity protein kinase TTK	5.1	5.1	5.1	pKd	1
Homo sapiens	Dual specificity testis-specific protein kinase 1	5.3	5.3	5.3	pKd	2
Homo sapiens	Ephrin type-A receptor 1	6	6	6	pKd	2
Homo sapiens	Ephrin type-A receptor 2	6.1	6.1	6.1	pKd	2
Homo sapiens	Ephrin type-A receptor 2	6.2	6.2	6.2	pKi	1
Homo sapiens	Ephrin type-A receptor 3	5.8	5.8	5.8	pKd	2
Homo sapiens	Ephrin type-A receptor 4	5.4	5.4	5.4	pKd	2
Homo sapiens	Ephrin type-A receptor 6	5.3	5.3	5.3	pKd	1
Homo sapiens	Ephrin type-A receptor 8	6.3	6.3	6.3	pKd	2
Homo sapiens	Ephrin type-B receptor 1	5.7	5.7	5.7	pKd	2
Homo sapiens	Ephrin type-B receptor 2	5.3	5.3	5.3	pKd	1
Homo sapiens	Ephrin type-B receptor 4	5.8	5.8	5.8	pKd	2
Homo sapiens	Epidermal growth factor receptor erbB1	5.8	5.8	5.8	pKi	1
Homo sapiens	Epithelial discoidin domain-containing receptor 1	7.6	7.6	7.6	pKd	2
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	5.7	5.7	5.7	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	6.3	6.3	6.3	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	6.1	6.1	6.1	pKi	1
Homo sapiens	Fibroblast growth factor receptor 2	6.2	6.2	6.2	pKd	2
Homo sapiens	Fibroblast growth factor receptor 3	6.1	6.1	6.1	pKd	4
Homo sapiens	Fibroblast growth factor receptor 3	6.2	6.2	6.2	pKi	1
Homo sapiens	Fibroblast growth factor receptor 4	5.1	5.1	5.1	pKd	2
Homo sapiens	G protein-coupled receptor kinase 4	6.4	6.4	6.4	pKd	1
Homo sapiens	Hepatocyte growth factor receptor	6.2	6.2	6.4	pKd	4
Homo sapiens	Hormonally up-regulated neu tumor-associated kinase	5	5	5	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	5.6	5.6	5.6	pKd	2
Homo sapiens	Insulin-like growth factor I receptor	6.3	6.3	6.3	pIC50	1
Homo sapiens	Insulin-like growth factor I receptor	6.1	6.1	6.1	pKd	2
Homo sapiens	Insulin receptor	6.2	6.2	6.3	pKd	3
Homo sapiens	Insulin receptor	6	6	6	pKi	1
Homo sapiens	Insulin receptor-related protein	6.5	6.5	6.6	pKd	3
Homo sapiens	Interleukin-1 receptor-associated kinase 3	5.3	5.3	5.3	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	5.4	5.4	5.4	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	5.6	5.6	5.6	pKi	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	6.2	6.2	6.2	pKi	1
Homo sapiens	Leukocyte tyrosine kinase receptor	5.1	5.1	5.1	pKd	2
Homo sapiens	Leukocyte tyrosine kinase receptor	6.3	6.3	6.3	pKi	1
Homo sapiens	LIM domain kinase 1	5.6	5.6	5.6	pKd	2
Homo sapiens	LIM domain kinase 1	6.1	6.1	6.1	pKi	1
Homo sapiens	LIM domain kinase 2	5.6	5.6	5.6	pKd	2
Homo sapiens	Macrophage colony stimulating factor receptor	5.8	5.8	5.8	pKd	2
Homo sapiens	Macrophage-stimulating protein receptor	5.9	5.9	5.9	pKd	1
Homo sapiens	Macrophage-stimulating protein receptor	6.1	6.1	6.1	pKi	1
Homo sapiens	MAP kinase-activated protein kinase 2	5.4	5.4	5.4	pKd	1
Homo sapiens	MAP kinase signal-integrating kinase 2	5.3	5.3	5.3	pKd	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	5.9	5.9	5.9	pKd	2
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	6	6	6	pKi	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	5.3	5.3	5.3	pKd	2
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	6	6	6	pKi	1
Homo sapiens	Maternal embryonic leucine zipper kinase	6.4	6.4	6.4	pIC50	1
Homo sapiens	Maternal embryonic leucine zipper kinase	6.6	6.6	6.6	pKd	2
Homo sapiens	Maternal embryonic leucine zipper kinase	7.4	7.4	7.4	pKi	1
Homo sapiens	Misshapen-like kinase 1	6	6	6	pKd	1
Homo sapiens	Misshapen-like kinase 1	5.2	5.2	5.2	pKi	1
Homo sapiens	Mitogen-activated protein kinase 7	5.2	5.2	5.2	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 10	5.8	5.8	5.8	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 10	6.4	6.4	6.4	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 11	6.2	6.2	6.2	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase 12	6.7	6.7	6.7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 13	6.8	6.8	6.8	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	6	6	6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	5.7	5.7	5.7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	5.6	5.6	5.6	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	5.6	5.6	5.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	6.4	6.4	6.4	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	7.1	7.1	7.1	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.6	5.6	5.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	6.5	6.5	6.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	5.6	5.6	5.6	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	7.1	7.1	7.3	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	6.8	6.8	6.8	pKi	1
Homo sapiens	Mixed lineage kinase 7	5.6	5.6	5.6	pKd	2
Homo sapiens	Mixed lineage kinase 7	5.1	5.1	5.1	pKi	1
Homo sapiens	Muscle, skeletal receptor tyrosine protein kinase	6.5	6.5	6.5	pKd	2
Homo sapiens	Myosin light chain kinase	7.8	7.8	7.8	pKd	1
Homo sapiens	myosin light chain kinase 2	7.4	7.4	7.4	pKd	2
Homo sapiens	Myosin light chain kinase family member 4	5.7	5.7	5.7	pKd	2
Gallus gallus	Myosin light chain kinase, smooth muscle	7.8	7.8	7.8	pKd	1
Homo sapiens	Nerve growth factor receptor Trk-A	7.4	7.4	8.5	pKd	4
Homo sapiens	Nerve growth factor receptor Trk-A	6.5	6.5	6.5	pKi	1
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	6.6	6.6	6.6	pKd	2
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	6.5	6.5	6.5	pKi	1
Homo sapiens	Non-receptor tyrosine-protein kinase TNK1	7.1	7.1	7.1	pKd	3
Homo sapiens	NT-3 growth factor receptor	6.7	6.7	6.7	pKd	2
Homo sapiens	NT-3 growth factor receptor	6.2	6.2	6.2	pKi	1
Homo sapiens	NUAK family SNF1-like kinase 1	6.7	6.7	6.7	pKd	2
Homo sapiens	NUAK family SNF1-like kinase 2	6.3	6.3	6.3	pKd	2
Homo sapiens	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha	6.9	6.9	6.9	pKd	2
Homo sapiens	Phosphatidylinositol-5-phosphate 4-kinase type-2 beta	6.9	6.9	6.9	pKd	2
Homo sapiens	Phosphorylase kinase gamma subunit 1	5.7	5.7	5.7	pKd	2
Homo sapiens	Phosphorylase kinase gamma subunit 2	5.4	5.4	5.4	pKd	1
Homo sapiens	PITSLRE serine/threonine-protein kinase CDC2L1	6.5	6.5	6.5	pKd	2
Homo sapiens	PITSLRE serine/threonine-protein kinase CDC2L2	6.6	6.6	6.6	pKd	2
Homo sapiens	Platelet-derived growth factor receptor alpha	5.8	5.8	5.8	pKd	2
Homo sapiens	Platelet-derived growth factor receptor beta	6.5	6.5	6.5	pKd	2
Homo sapiens	Platelet-derived growth factor receptor beta	6.4	6.4	6.4	pKi	1
Homo sapiens	Protein kinase C theta	5.3	5.3	5.3	pKd	1
Homo sapiens	Protein kinase C zeta	5.1	5.1	5.1	pKi	1
Homo sapiens	Protein kinase N1	5.8	5.8	5.8	pKd	2
Homo sapiens	Protein kinase N2	5.3	5.3	5.3	pKd	1
Homo sapiens	Protein kinase N2	5.3	5.3	5.3	pKi	1
Homo sapiens	Protein tyrosine kinase 2 beta	5.6	5.6	5.6	pKd	2
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	5.8	5.8	5.8	pKd	2
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	6.2	6.2	6.2	pKd	2
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	6.8	6.8	6.8	pKi	1
Homo sapiens	Putative uncharacterized serine/threonine-protein kinase SgK110	6.3	6.3	6.3	pKd	1
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 1	6.7	6.7	6.7	pIC50	1
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 1	7.7	7.7	7.7	pKd	3
Mus musculus	Receptor-interacting serine/threonine-protein kinase 1	6	6	6	pIC50	2
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 4	6.5	6.5	6.5	pKd	1
Homo sapiens	Receptor tyrosine-protein kinase erbB-3	5.2	5.2	5.2	pKd	1
Homo sapiens	Ribosomal protein S6 kinase 1	5.5	5.5	5.5	pKi	1
Homo sapiens	Ribosomal protein S6 kinase alpha 1	5.1	5.1	5.1	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 2	5.7	5.7	5.7	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 3	5.2	5.2	5.2	pKd	4
Homo sapiens	Serine/threonine-protein kinase 10	6.9	6.9	6.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase 11	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase 16	6.2	6.2	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase 17A	5.1	5.1	5.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase 2	7.1	7.1	7.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase 2	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase 24	5.4	5.4	5.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase 25	5.3	5.3	5.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase 38-like	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	7.7	6.5	9.6	pIC50	20
Homo sapiens	Serine/threonine-protein kinase Aurora-A	8.8	7.8	9.5	pKd	10
Homo sapiens	Serine/threonine-protein kinase Aurora-A	9.2	8.5	9.2	pKi	14
Homo sapiens	Serine/threonine-protein kinase Aurora-B	7.4	6.1	7.8	pIC50	14
Homo sapiens	Serine/threonine-protein kinase Aurora-B	8.1	8.1	8.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase Aurora-B	7.8	7.8	8.7	pKi	13
Homo sapiens	Serine/threonine-protein kinase Aurora-C	8.3	7.2	8.3	pIC50	3
Homo sapiens	Serine/threonine-protein kinase Aurora-C	8.2	8.2	8.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase Aurora-C	8.3	8.3	8.3	pKi	10
Homo sapiens	Serine/threonine-protein kinase Chk1	5.1	5.1	5.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase c-TAK1	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase c-TAK1	5.4	5.4	5.4	pKi	1
Homo sapiens	Serine/threonine-protein kinase D2	5.3	5.3	5.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase DCLK3	5.4	5.4	5.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase GAK	5.5	5.5	5.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase LATS1	5.3	5.3	5.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase LATS2	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase MARK1	5.3	5.3	5.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST1	6.7	6.7	6.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST2	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST4	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase Nek5	5.4	5.4	5.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK7	5.1	5.1	5.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 1	5.4	5.4	5.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase PAK 1	5.1	5.1	5.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK 2	5.2	5.2	5.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase PAK 3	5.5	5.5	5.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase PAK 4	5.4	5.4	5.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase PAK 4	5.4	5.4	5.4	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK6	5	5	5	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK7	5.5	5.5	5.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	6.6	6.6	6.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-2	5.3	5.3	5.3	pKd	1
Mycobacterium tuberculosis	Serine/threonine-protein kinase pknB	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK4	8	8	8.1	pKd	3
Homo sapiens	Serine/threonine-protein kinase PLK4	8	7.6	8	pKi	3
Homo sapiens	Serine/threonine-protein kinase PRP4 homolog	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase receptor R3	5	5	5	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO1	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIO2	6.6	6.6	6.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO3	6.2	6.2	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK1	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK2	5.8	5.8	5.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK2	6	6	6	pKi	1
Homo sapiens	Serine/threonine-protein kinase SRPK1	7.1	7.1	7.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase SRPK2	6.2	6.2	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase SRPK3	6.6	6.6	6.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO1	6.5	6.5	6.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO1	7.1	7.1	7.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase TAO2	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO3	7.1	7.1	7.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase TBK1	6.3	6.3	6.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase tousled-like 1	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK3	6.5	6.5	6.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase WEE1	5.5	5.5	5.5	pKd	2
Homo sapiens	SPS1/STE20-related protein kinase YSK4	7.3	7.3	7.3	pKd	1
Homo sapiens	Stem cell growth factor receptor	6.5	5.6	6.6	pKd	15
Homo sapiens	TGF-beta receptor type I	5.1	5.1	5.1	pKd	1
Homo sapiens	TRAF2- and NCK-interacting kinase	5.8	5.8	5.8	pKd	2
Homo sapiens	Tyrosine kinase non-receptor protein 2	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase ABL	8	5.1	8.5	pKd	22
Homo sapiens	Tyrosine-protein kinase ABL	7.5	7.4	7.8	pKi	3
Mus musculus	Tyrosine-protein kinase ABL	5.3	5.3	5.3	pIC50	1
Homo sapiens	Tyrosine-protein kinase ABL2	8.4	8.4	8.4	pKd	3
Homo sapiens	Tyrosine-protein kinase BLK	5.7	5.7	5.7	pKd	2
Homo sapiens	Tyrosine-protein kinase BLK	7.5	7.5	7.5	pKi	1
Homo sapiens	Tyrosine-protein kinase BMX	5.6	5.6	5.6	pKd	2
Homo sapiens	Tyrosine-protein kinase BTK	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase BTK	5.8	5.8	5.8	pKi	1
Homo sapiens	Tyrosine-protein kinase CSK	5.3	5.3	5.3	pKd	2
Homo sapiens	Tyrosine-protein kinase FER	5.4	5.4	5.4	pKd	1
Homo sapiens	Tyrosine-protein kinase FES	5.1	5.1	5.1	pKd	1
Homo sapiens	Tyrosine-protein kinase FGR	6.1	6.1	6.1	pKd	2
Homo sapiens	Tyrosine-protein kinase FRK	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase FYN	6.3	6.3	6.3	pKd	2
Homo sapiens	Tyrosine-protein kinase FYN	5.5	5.5	5.5	pKi	1
Homo sapiens	Tyrosine-protein kinase HCK	5.2	5.2	5.2	pKd	1
Homo sapiens	Tyrosine-protein kinase ITK/TSK	6.5	6.5	6.5	pKd	2
Homo sapiens	Tyrosine-protein kinase ITK/TSK	7.2	7.2	7.2	pKi	1
Homo sapiens	Tyrosine-protein kinase JAK1	5.2	5.2	5.2	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK2	6.7	6.7	6.7	pKd	6
Homo sapiens	Tyrosine-protein kinase JAK2	6.6	6.6	6.6	pKi	2
Homo sapiens	Tyrosine-protein kinase JAK3	6.2	6.2	6.2	pKd	4
Homo sapiens	Tyrosine-protein kinase LCK	7.2	7.2	7.2	pKd	2
Homo sapiens	Tyrosine-protein kinase LCK	6.9	6.9	7.1	pKi	2
Homo sapiens	Tyrosine-protein kinase Lyn	6.2	6.2	6.2	pKd	2
Homo sapiens	Tyrosine-protein kinase Lyn	6.6	6.6	6.6	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	7.5	7.5	7.5	pIC50	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	7.9	6.9	8.4	pKd	13
Homo sapiens	Tyrosine-protein kinase receptor FLT3	7.5	6.4	7.5	pKi	5
Homo sapiens	Tyrosine-protein kinase receptor RET	7.6	7.6	8.1	pKd	7
Homo sapiens	Tyrosine-protein kinase receptor RET	7.9	7.9	7.9	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	6.6	6.6	6.6	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	5.9	5.9	5.9	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor UFO	6.7	6.7	6.7	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor UFO	6.7	6.7	6.7	pKi	1
Gallus gallus	Tyrosine-protein kinase SRC	6.5	6.5	6.5	pIC50	1
Homo sapiens	Tyrosine-protein kinase SRC	6.8	6.8	6.8	pKd	2
Homo sapiens	Tyrosine-protein kinase SRC	6.8	6.8	6.8	pKi	1
Homo sapiens	Tyrosine-protein kinase SYK	5.8	5.8	5.8	pKd	2
Homo sapiens	Tyrosine-protein kinase TEC	5.1	5.1	5.1	pKd	1
Homo sapiens	Tyrosine-protein kinase TIE-2	6.4	6.4	6.4	pKd	2
Homo sapiens	Tyrosine-protein kinase TXK	5.6	5.6	5.6	pKd	2
Homo sapiens	Tyrosine-protein kinase TYK2	5.2	5.2	6.3	pKd	4
Homo sapiens	Tyrosine-protein kinase TYK2	6.7	6.7	6.7	pKi	2
Homo sapiens	Tyrosine-protein kinase YES	6.3	6.3	6.3	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	7	7	7	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	5.9	5.9	5.9	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 2	5.7	5.7	5.7	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 2	6.5	6.5	6.5	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 3	5.7	5.7	5.7	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 3	5.8	5.8	5.8	pKi	1
Homo sapiens	Wee1-like protein kinase 2	5.4	5.4	5.4	pKd	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 R
81

2 P
82

3 L
83

4 G
84

5 K
85

6 G
86

7 K
87

8 F
88

9 G
89

10 N
90

11 V
91

12 Y
92

13 L
93

14 V
103

15 A
104

16 L
105

17 K
106

18 V
107

19 L
108

20 Q
121

•

••

•

αC

b.l

21 L
122

22 R
123

23 R
124

24 E
125

25 I
126

26 E
127

27 I
128

28 Q
129

29 A
130

30 H
131

31 L
132

32 H
133

33 P
135

34 N
136

35 I
137

36 L
138

37 R
139

38 L
140

39 Y
141

40 N
142

•

hinge

linker

αD

αE

41 Y
143

42 Y
151

43 L
152

44 I
153

45 L
154

46 E
155

47 Y
156

48 A
157

49 P
158

50 R
159

51 G
160

52 E
161

53 L
162

54 Y
163

55 K
164

56 E
165

57 L
166

58 Q
167

59 K
168

60 Y
190

•

••

•

αE

c.l

VII

VIII

61 C
191

62 H
192

63 G
193

64 K
194

65 K
195

66 V
196

67 I
197

68 H
198

69 R
199

70 D
200

71 I
201

72 K
202

73 P
203

74 E
204

75 N
205

76 L
206

77 L
207

78 L
208

79 I
216

80 A
217

•

DFG

a.l

81 D
218

82 F
219

83 G
220

84 _
_

85 _
_

•

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: