KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	CDK2
Family:	CDK
Group:	CMGC
Species:	HUMAN
IUPHAR/BPS ID:	1973
PDB:	3TI1
sc-PDB:
KIDFamMap:	Search
Release date:	2012-08-22
PubMed:	22893598
Chain:	A
(Alternate) Model:	A
Orthosteric ligand:	B49

More entries for 3TI1
3TI1	Alternative model:	B	Chain:	A

Structural information
DFG conformation:	in
αC-helix conformation:	out
G-rich loop angle (distance):	46.9° (13.5Å)
G-rich loop rotation:	65.5°
Quality Score:	8
Resolution:	1.99 Å
Missing Residues:	0
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets
front

Pocket alignment
Uniprot sequence:	EKIGEGTYGVVYKVALKKITAIREISLLKELNPNIVKLLDVYLVFEFLH-QDLKKFMDAFCHSHRVLHRDLKPQNLLILADFGLA
Sequence structure:	EKIGEGTYGVVYKVALKKITAIREISLLKELNPNIVKLLDVYLVFEFLH_QDLKKFMDAFCHSHRVLHRDLKPQNLLILADFGLA

Ligand affinity
ChEMBL ID:	CHEMBL535
Bioaffinities:	1059 records for 259 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	3-phosphoinositide dependent protein kinase-1	5.5	5.5	5.5	pKd	3
Homo sapiens	Adaptor-associated kinase	8	6.9	8	pKd	4
Homo sapiens	ALK tyrosine kinase receptor	5.6	5.6	7.3	pIC50	2
Homo sapiens	ALK tyrosine kinase receptor	6.8	6.8	6.8	pKd	3
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	7.7	7.3	7.7	pKd	5
Homo sapiens	AMP-activated protein kinase, alpha-2 subunit	7.1	7.1	7.1	pKd	3
Homo sapiens	Ankyrin repeat and protein kinase domain-containing protein 1	6.5	6.5	6.5	pKd	3
Homo sapiens	BMP-2-inducible protein kinase	8.3	7.4	8.3	pKd	5
Homo sapiens	Bone morphogenetic protein receptor type-1B	5.6	5.6	5.6	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-2	6.2	6.2	6.2	pKd	3
Homo sapiens	BR serine/threonine-protein kinase 1	5.5	5.5	5.5	pKd	3
Homo sapiens	BR serine/threonine-protein kinase 2	6	6	6	pKd	3
Plasmodium falciparum (isolate 3D7)	Calcium-dependent protein kinase 1	5.9	5.9	5.9	pKd	1
Homo sapiens	CaM kinase I alpha	6	5.7	6	pKd	4
Homo sapiens	CaM kinase I delta	6.3	6	6.3	pKd	4
Homo sapiens	CaM kinase I gamma	6.4	6	6.4	pKd	3
Homo sapiens	CaM kinase II alpha	7.1	6.4	7.1	pKd	5
Homo sapiens	CaM kinase II beta	5.9	5.5	5.9	pKd	4
Homo sapiens	CaM kinase II delta	6.4	6	6.4	pKd	4
Homo sapiens	CaM kinase II gamma	6.2	6.1	6.4	pKd	6
Homo sapiens	CaM kinase IV	6.1	6.1	6.1	pKd	3
Homo sapiens	CaM-kinase kinase alpha	6.4	6.1	6.4	pKd	4
Homo sapiens	CaM-kinase kinase beta	5.8	5.2	5.8	pKd	4
Homo sapiens	Casein kinase I alpha	6.3	6.3	7	pKd	2
Homo sapiens	Casein kinase I delta	7.8	7.8	7.8	pKd	3
Homo sapiens	Casein kinase I epsilon	7.9	7.9	7.9	pKd	3
Homo sapiens	Casein kinase I gamma 1	6	6	6	pKd	3
Homo sapiens	Casein kinase I gamma 2	7	7	7	pKd	3
Homo sapiens	Casein kinase II alpha	7.1	6.1	7.1	pKd	3
Homo sapiens	Casein kinase II alpha (prime)	6.4	6.4	6.8	pKd	3
Homo sapiens	Casein kinase I isoform alpha-like	6.3	6.3	6.3	pKd	2
Homo sapiens	Casein kinase I isoform gamma-3	6.6	6.6	6.6	pKd	3
Homo sapiens	Citron Rho-interacting kinase	5.4	5.4	5.4	pKd	3
Homo sapiens	c-Jun N-terminal kinase 2	5.6	5.6	5.6	pKd	1
Homo sapiens	c-Jun N-terminal kinase 3	5.4	5.4	5.4	pKd	1
Homo sapiens	Cyclin-dependent kinase 4	5.2	5.2	5.7	pKd	2
Homo sapiens	Cyclin-dependent kinase 5	5.2	5.2	5.2	pKd	1
Homo sapiens	Cyclin-dependent kinase 7	6.5	6.5	6.5	pKd	3
Homo sapiens	Cyclin-dependent kinase-like 2	6	6	6	pKd	2
Homo sapiens	Death-associated protein kinase 1	6.9	6.9	6.9	pKd	3
Homo sapiens	Death-associated protein kinase 2	6.8	6.3	6.8	pKd	5
Homo sapiens	Death-associated protein kinase 3	7	6.5	7.7	pKd	6
Homo sapiens	Discoidin domain-containing receptor 2	5.5	5.5	5.5	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6.9	6.9	6.9	pKd	3
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	7	7	7	pKd	3
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 3	5.8	5.8	5.8	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 4	6.2	6.2	6.2	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	7.3	7.3	7.3	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	5.3	5.3	5.3	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	7.7	6.7	7.7	pKd	6
Homo sapiens	Dual specificity protein kinase CLK4	7.5	7.1	7.5	pKd	6
Homo sapiens	Dual specificity protein kinase TTK	7.2	6.6	7.2	pKd	5
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	6.7	6.7	6.7	pKd	2
Homo sapiens	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	5.6	5.6	5.6	pKd	3
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 2	6.2	6.2	6.2	pKd	2
Homo sapiens	Dual specificty protein kinase CLK1	7.7	7	7.7	pKd	6
Homo sapiens	Ephrin type-A receptor 3	5.7	5.7	5.7	pKd	3
Homo sapiens	Ephrin type-A receptor 5	5.2	5.2	5.9	pKd	2
Homo sapiens	Ephrin type-A receptor 6	6	5.7	6	pKd	4
Homo sapiens	Ephrin type-A receptor 7	5.6	5.6	6.2	pKd	5
Homo sapiens	Ephrin type-B receptor 1	6.3	6	6.3	pKd	5
Homo sapiens	Ephrin type-B receptor 4	5.5	5.5	5.7	pKd	2
Homo sapiens	Epidermal growth factor receptor erbB1	6.8	4.8	6.8	pIC50	4
Homo sapiens	Epidermal growth factor receptor erbB1	5.2	5.2	6.1	pKd	5
Homo sapiens	Epithelial discoidin domain-containing receptor 1	5.7	5.7	5.7	pKd	3
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	6.8	6.8	6.8	pKd	3
Homo sapiens	Fibroblast growth factor receptor 1	6	5.5	6.8	pIC50	3
Homo sapiens	Fibroblast growth factor receptor 1	6.3	5.8	6.3	pKd	4
Homo sapiens	Fibroblast growth factor receptor 2	6.2	6.2	6.3	pKd	5
Homo sapiens	Fibroblast growth factor receptor 3	6.5	5.9	6.5	pKd	7
Homo sapiens	Fibroblast growth factor receptor 4	5.7	5.7	5.7	pKd	1
Homo sapiens	Focal adhesion kinase 1	5.8	5.8	5.8	pIC50	1
Homo sapiens	Focal adhesion kinase 1	6.4	6.2	6.4	pKd	5
Homo sapiens	G protein-coupled receptor kinase 4	6.9	6.9	6.9	pKd	2
Homo sapiens	G protein-coupled receptor kinase 7	6.8	6.8	6.8	pKd	2
Homo sapiens	Hepatocyte growth factor receptor	5	5	5.7	pIC50	2
Homo sapiens	Hepatocyte growth factor receptor	5.3	5.1	5.9	pKd	5
Homo sapiens	Homeodomain-interacting protein kinase 1	7.3	7.3	7.3	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 2	7.5	7.5	7.5	pKd	2
Homo sapiens	Homeodomain-interacting protein kinase 3	7.4	7.4	7.4	pKd	2
Homo sapiens	Homeodomain-interacting protein kinase 4	6.8	6.8	6.8	pKd	2
Homo sapiens	Hormonally up-regulated neu tumor-associated kinase	6.3	6.3	6.3	pKd	2
Homo sapiens	Inhibitor of nuclear factor kappa B kinase alpha subunit	6.3	6.3	6.3	pKd	2
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	6.2	6.2	6.2	pKd	3
Homo sapiens	Insulin-like growth factor I receptor	5.6	5.6	5.6	pKd	3
Homo sapiens	Insulin receptor	5.5	5.5	5.5	pIC50	1
Homo sapiens	Insulin receptor	6.3	6.3	6.8	pKd	5
Homo sapiens	Insulin receptor-related protein	6.4	6.4	6.4	pKd	3
Homo sapiens	Interferon-induced, double-stranded RNA-activated protein kinase	6.2	6.2	6.2	pKd	3
Homo sapiens	Interleukin-1 receptor-associated kinase 1	7.9	7.9	7.9	pKd	2
Homo sapiens	Interleukin-1 receptor-associated kinase 3	6	6	6	pKd	3
Homo sapiens	Interleukin-1 receptor-associated kinase 4	7.2	7.2	7.2	pKd	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	7.6	7.6	7.8	pIC50	2
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	7	7	7.1	pKd	2
Homo sapiens	Leukocyte tyrosine kinase receptor	5.8	5.8	5.8	pKd	3
Homo sapiens	Macrophage colony stimulating factor receptor	6.8	6.8	7.5	pIC50	2
Homo sapiens	Macrophage colony stimulating factor receptor	8.7	8.6	8.7	pKd	3
Homo sapiens	MAP kinase-interacting serine/threonine-protein kinase MNK1	5.4	5.4	5.4	pKd	1
Homo sapiens	MAP kinase signal-integrating kinase 2	5.2	5.2	5.2	pKd	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	6.5	6.5	6.5	pKd	4
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	5.4	5.4	5.4	pKd	3
Homo sapiens	Maternal embryonic leucine zipper kinase	6.5	6.5	6.5	pKd	3
Homo sapiens	Microtubule-associated serine/threonine-protein kinase 1	6.7	6.7	6.7	pKd	2
Homo sapiens	Misshapen-like kinase 1	7.5	7.5	7.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase 7	5	5	5	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 11	5.9	5.9	5.9	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase 12	7	7	7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 13	7	7	7	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 15	5.9	5.9	5.9	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	7.2	7.2	7.2	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	6.7	6.7	6.7	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	5.3	5.3	5.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	7	7	7	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	5.5	5.5	5.5	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	7.8	7.8	7.8	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	7.5	7.5	7.5	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	6.8	6.8	6.8	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	6.9	6.9	6.9	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	7.4	7.1	7.4	pKd	5
Homo sapiens	Muscle, skeletal receptor tyrosine protein kinase	6.3	6.3	6.3	pKd	3
Homo sapiens	Myosin IIIA	5.5	5.5	5.5	pKd	1
Homo sapiens	Myosin-IIIB	5.4	5.4	5.4	pKd	3
Homo sapiens	Myosin light chain kinase	7.6	7.6	7.6	pKd	1
Homo sapiens	myosin light chain kinase 2	7.3	7.2	7.3	pKd	5
Homo sapiens	Myosin light chain kinase family member 4	7.8	7.8	7.8	pKd	3
Gallus gallus	Myosin light chain kinase, smooth muscle	7.6	7.6	7.6	pKd	1
Homo sapiens	Myosin light chain kinase, smooth muscle	6.6	6.6	7.6	pKd	4
Homo sapiens	Nerve growth factor receptor Trk-A	7	6.7	7	pKd	5
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	6.2	6.2	6.2	pKd	3
Homo sapiens	Non-receptor tyrosine-protein kinase TNK1	6.2	6.2	6.2	pKd	3
Homo sapiens	NT-3 growth factor receptor	5.3	5.3	5.3	pKd	3
Homo sapiens	NUAK family SNF1-like kinase 1	7.3	7.3	7.3	pKd	3
Homo sapiens	NUAK family SNF1-like kinase 2	6.8	6.8	6.8	pKd	3
Homo sapiens	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha	5.3	5.3	5.3	pKd	3
Homo sapiens	Phosphatidylinositol-5-phosphate 4-kinase type-2 beta	7.4	7.4	7.4	pKd	3
Homo sapiens	Phosphorylase kinase gamma subunit 1	8.3	7.2	8.3	pKd	5
Homo sapiens	Phosphorylase kinase gamma subunit 2	8.2	7.4	8.2	pKd	5
Homo sapiens	Platelet-derived growth factor receptor alpha	6.9	6.9	6.9	pIC50	1
Homo sapiens	Platelet-derived growth factor receptor alpha	9.1	9.1	9.1	pKd	3
Homo sapiens	Platelet-derived growth factor receptor beta	7.1	4.1	8.7	pIC50	16
Homo sapiens	Platelet-derived growth factor receptor beta	10.1	9.7	10.1	pKd	5
Homo sapiens	Platelet-derived growth factor receptor beta	8.1	8.1	8.1	pKi	1
Homo sapiens	Protein kinase C alpha	5.2	5.2	5.2	pKd	1
Homo sapiens	Protein kinase C mu	6.5	6.5	6.5	pKd	3
Homo sapiens	Protein kinase C nu	6.6	6.6	6.6	pKd	3
Homo sapiens	Protein kinase C theta	5.4	5.4	5.4	pKd	3
Homo sapiens	Protein kinase N1	6.2	6.2	6.2	pKd	3
Homo sapiens	Protein kinase N2	5.9	5.9	5.9	pKd	3
Homo sapiens	Protein tyrosine kinase 2 beta	7.1	7.1	7.1	pKd	3
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	7.6	7.6	7.6	pKd	3
Homo sapiens	Putative uncharacterized serine/threonine-protein kinase SgK110	5.7	5.7	5.7	pKd	2
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 1	6.4	6.4	6.4	pKd	3
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 4	5.7	5.7	5.7	pKd	2
Homo sapiens	Rho-associated protein kinase 1	6.3	6.3	6.3	pKd	2
Homo sapiens	Rho-associated protein kinase 2	6.9	6.9	6.9	pKd	2
Homo sapiens	Rhodopsin kinase	6.5	6.5	6.5	pKd	2
Homo sapiens	Ribosomal protein S6 kinase 1	6.7	6.7	7.3	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 1	6.9	6.9	6.9	pIC50	2
Homo sapiens	Ribosomal protein S6 kinase alpha 1	6.2	5.3	7	pKd	12
Homo sapiens	Ribosomal protein S6 kinase alpha 2	7.2	5.1	7.8	pKd	16
Homo sapiens	Ribosomal protein S6 kinase alpha 3	6.7	6.7	6.7	pIC50	2
Homo sapiens	Ribosomal protein S6 kinase alpha 3	6.2	5.7	7.3	pKd	10
Homo sapiens	Ribosomal protein S6 kinase alpha 4	5.7	5.3	7	pKd	12
Homo sapiens	Ribosomal protein S6 kinase alpha 5	6.6	5.1	7.8	pKd	16
Homo sapiens	Ribosomal protein S6 kinase alpha 6	5.6	5.6	5.6	pKd	6
Homo sapiens	Serine/threonine-protein kinase 10	7.7	6.2	7.7	pKd	4
Homo sapiens	Serine/threonine-protein kinase 11	7.4	7.4	7.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase 16	6.6	6.4	6.6	pKd	5
Homo sapiens	Serine/threonine-protein kinase 17A	9	7.7	9	pKd	5
Homo sapiens	Serine/threonine-protein kinase 17B	7	6.7	7	pKd	5
Homo sapiens	Serine/threonine-protein kinase 2	7.3	7.1	7.3	pKd	5
Homo sapiens	Serine/threonine-protein kinase 24	7.2	7.2	7.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase 25	6.5	6.5	6.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase 33	7.8	7.8	7.8	pKd	3
Homo sapiens	Serine/threonine-protein kinase 35	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase 38	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase 38-like	6	5.8	6	pKd	4
Homo sapiens	Serine/threonine-protein kinase AKT2	5.6	5.6	5.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase Aurora-A	5.7	5.7	5.7	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	5.8	5.2	5.8	pKd	4
Homo sapiens	Serine/threonine-protein kinase Aurora-B	5.8	5.8	5.8	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	6.4	6.4	6.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase Aurora-C	6.7	6.5	6.7	pKd	5
Homo sapiens	Serine/threonine-protein kinase Chk1	7.1	7.1	7.1	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Chk1	6.5	6.5	6.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase Chk2	7.8	7.8	7.8	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Chk2	8	8	8.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase c-TAK1	6.4	6.2	6.4	pKd	4
Homo sapiens	Serine/threonine-protein kinase D2	6.4	6.4	6.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase DCLK1	6.4	6.4	6.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase DCLK2	5.6	5.6	5.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase DCLK3	7	7	7	pKd	3
Homo sapiens	Serine/threonine-protein kinase GAK	7.7	6.9	7.7	pKd	5
Homo sapiens	Serine/threonine-protein kinase ICK	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase LATS1	6.2	6.2	6.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase LATS2	6.3	6.3	6.3	pKd	3
Homo sapiens	Serine/threonine-protein kinase MARK1	5.9	5.9	5.9	pKd	3
Homo sapiens	Serine/threonine-protein kinase MST1	7.7	7	7.7	pKd	5
Homo sapiens	Serine/threonine-protein kinase MST2	7.3	7.3	7.3	pKd	3
Mus musculus	Serine/threonine-protein kinase MST2	6.8	6.8	6.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST4	6.5	6.5	6.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase NEK2	4.9	4.9	4.9	pIC50	1
Homo sapiens	Serine/threonine-protein kinase NEK2	5.9	5.9	6.3	pKd	5
Homo sapiens	Serine/threonine-protein kinase NEK7	5.4	5.4	5.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase NIM1	6.1	6.1	6.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase OSR1	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase PAK 3	7.8	7.8	7.8	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK 4	6.3	6.3	6.3	pIC50	1
Homo sapiens	Serine/threonine-protein kinase PAK 4	5.6	5.6	5.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK 4	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK6	5.6	5.6	5.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK6	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK7	6.2	6.2	6.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK7	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	6.8	6.8	6.9	pKd	5
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-2	5.9	5.9	5.9	pKd	3
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-3	5.8	5.8	5.8	pKd	3
Homo sapiens	Serine/threonine-protein kinase PFTAIRE-1	6.6	6.6	6.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase PIM2	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase PIM3	5.6	5.6	5.6	pKd	3
Mycobacterium tuberculosis	Serine/threonine-protein kinase pknB	7.1	7.1	7.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK2	5.3	5.3	5.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase PLK4	6.7	6.4	6.7	pKd	5
Homo sapiens	Serine/threonine-protein kinase PRP4 homolog	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO1	7.5	7.5	7.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase RIO2	7.3	7.3	7.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIO3	5.4	5.4	5.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase SBK1	6.7	6.7	6.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase Sgk3	6.7	6.7	6.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK1	5.5	5.5	5.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase SIK2	6.2	6.2	6.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase SRPK1	6.6	6.6	6.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase SRPK2	6.7	6.7	6.7	pKd	3
Homo sapiens	Serine/threonine-protein kinase SRPK3	7.2	7.2	7.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase TAO1	6.1	6.1	6.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase TAO3	6.7	6.7	6.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase TBK1	6.9	6.9	6.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase tousled-like 1	6.1	6.1	6.1	pKd	3
Homo sapiens	Serine/threonine-protein kinase tousled-like 2	6.5	6.5	6.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase ULK1	7.6	7.6	7.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase ULK2	7.9	7.9	7.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase ULK3	7.4	7.4	7.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase WEE1	6	6	6	pKd	3
Homo sapiens	SNF-related serine/threonine-protein kinase	6.2	6.2	6.2	pKd	1
Homo sapiens	SPS1/STE20-related protein kinase YSK4	7.8	7.8	7.8	pKd	2
Homo sapiens	STE20/SPS1-related proline-alanine-rich protein kinase	6.9	6.9	6.9	pKd	2
Homo sapiens	Stem cell growth factor receptor	8	6.5	9.2	pIC50	9
Homo sapiens	Stem cell growth factor receptor	9.4	6.4	9.7	pKd	23
Homo sapiens	Stem cell growth factor receptor	8.4	8.4	8.4	pKi	1
Homo sapiens	Testis-specific serine/threonine-protein kinase 1	5.2	5.2	5.2	pKd	3
Homo sapiens	TRAF2- and NCK-interacting kinase	7.6	7.6	7.6	pKd	6
Homo sapiens	Tyrosine kinase non-receptor protein 2	5.1	5.1	5.7	pKd	3
Homo sapiens	Tyrosine-protein kinase ABL	6.3	5.8	6.4	pIC50	3
Homo sapiens	Tyrosine-protein kinase ABL	6.1	5.4	7.3	pKd	36
Homo sapiens	Tyrosine-protein kinase ABL2	6	5.9	6	pKd	4
Homo sapiens	Tyrosine-protein kinase BLK	7.2	7.2	7.2	pKd	3
Homo sapiens	Tyrosine-protein kinase BRK	5.3	5.3	5.3	pKd	1
Homo sapiens	Tyrosine-protein kinase BTK	5.7	5.7	5.7	pKd	1
Homo sapiens	Tyrosine-protein kinase CTK	5.1	5.1	5.1	pKd	1
Homo sapiens	Tyrosine-protein kinase FER	6	5.9	6	pKd	4
Homo sapiens	Tyrosine-protein kinase FES	6	6	6	pKd	3
Homo sapiens	Tyrosine-protein kinase FGR	6.6	6.5	6.6	pKd	5
Homo sapiens	Tyrosine-protein kinase FRK	6.3	6.3	6.3	pKd	3
Homo sapiens	Tyrosine-protein kinase FYN	6.3	5.4	6.3	pKd	4
Homo sapiens	Tyrosine-protein kinase HCK	6.7	6.7	6.7	pIC50	1
Homo sapiens	Tyrosine-protein kinase HCK	6.1	5.5	6.1	pKd	4
Homo sapiens	Tyrosine-protein kinase ITK/TSK	7.9	7.9	7.9	pKd	3
Homo sapiens	Tyrosine-protein kinase JAK1	7.3	5.2	8.1	pKd	14
Homo sapiens	Tyrosine-protein kinase JAK2	6.4	6	6.4	pKd	8
Homo sapiens	Tyrosine-protein kinase JAK3	5.9	5.9	5.9	pKd	6
Homo sapiens	Tyrosine-protein kinase LCK	8.1	8.1	8.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase LCK	6.6	5.9	6.6	pKd	4
Homo sapiens	Tyrosine-protein kinase Lyn	6.6	6.3	6.6	pKd	5
Homo sapiens	Tyrosine-protein kinase receptor FLT3	7.9	6.3	8.6	pIC50	10
Homo sapiens	Tyrosine-protein kinase receptor FLT3	9	8	9.7	pKd	21
Homo sapiens	Tyrosine-protein kinase receptor RET	6.7	5.9	6.7	pIC50	3
Homo sapiens	Tyrosine-protein kinase receptor RET	7.9	7.7	8.2	pKd	10
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	5.4	5.4	5.4	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	7.3	7.3	7.3	pKd	3
Homo sapiens	Tyrosine-protein kinase receptor UFO	8.1	8.1	8.1	pIC50	2
Homo sapiens	Tyrosine-protein kinase receptor UFO	8.1	8.1	8.1	pKd	3
Gallus gallus	Tyrosine-protein kinase SRC	6.3	6.3	6.3	pIC50	1
Homo sapiens	Tyrosine-protein kinase SRC	6.4	6.4	6.8	pIC50	2
Homo sapiens	Tyrosine-protein kinase SRC	5.7	5.5	5.7	pKd	4
Homo sapiens	Tyrosine-protein kinase TYK2	5.8	5.8	6.4	pKd	10
Homo sapiens	Tyrosine-protein kinase YES	6.9	6.6	6.9	pKd	4
Mus musculus	ULK3 kinase	7	7	7	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 1	9	9	9	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 1	8.7	8.7	8.7	pKd	3
Homo sapiens	Vascular endothelial growth factor receptor 1	8.7	8.7	8.7	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 2	7.4	4.7	8.4	pIC50	45
Homo sapiens	Vascular endothelial growth factor receptor 2	8.8	7.5	9.7	pKd	6
Homo sapiens	Vascular endothelial growth factor receptor 2	8.1	8.1	8.5	pKi	4
Homo sapiens	Vascular endothelial growth factor receptor 3	8.1	8.1	8.1	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 3	7.3	7.3	7.5	pKd	5
Homo sapiens	Vascular endothelial growth factor receptor 3	7.8	7.8	7.8	pKi	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 E
8

2 K
9

3 I
10

4 G
11

5 E
12

6 G
13

7 T
14

8 Y
15

9 G
16

10 V
17

11 V
18

12 Y
19

13 K
20

14 V
30

15 A
31

16 L
32

17 K
33

18 K
34

19 I
35

20 T
47

••

•

αC

b.l

21 A
48

22 I
49

23 R
50

24 E
51

25 I
52

26 S
53

27 L
54

28 L
55

29 K
56

30 E
57

31 L
58

32 N
59

33 P
61

34 N
62

35 I
63

36 V
64

37 K
65

38 L
66

39 L
67

40 D
68

•

hinge

linker

αD

αE

41 V
69

42 Y
77

43 L
78

44 V
79

45 F
80

46 E
81

47 F
82

48 L
83

49 H
84

50 _
_

51 Q
85

52 D
86

53 L
87

54 K
88

55 K
89

56 F
90

57 M
91

58 D
92

59 A
93

60 F
117

••

•

•••

•

••••

•

αE

c.l

VII

VIII

61 C
118

62 H
119

63 S
120

64 H
121

65 R
122

66 V
123

67 L
124

68 H
125

69 R
126

70 D
127

71 L
128

72 K
129

73 P
130

74 Q
131

75 N
132

76 L
133

77 L
134

78 I
135

79 L
143

80 A
144

•

DFG

a.l

81 D
145

82 F
146

83 G
147

84 L
148

85 A
149

•

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: