KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	CDK2
Family:	CDK
Group:	CMGC
Species:	HUMAN
IUPHAR/BPS ID:	1973
PDB:	2UUE
sc-PDB:
KIDFamMap:	Search
Release date:	2007-03-27
PubMed:	16492568
Chain:	A
Orthosteric ligand:	MTZ

More entries for 2UUE
2UUE	Chain:	C

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	53° (15.7Å)
G-rich loop rotation:	74.5°
Quality Score:	8
Resolution:	2.06 Å
Missing Residues:	0
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets	Waters
front		Cluster I5	Ligand Yes	Protein Yes

Pocket alignment
Uniprot sequence:	EKIGEGTYGVVYKVALKKITAIREISLLKELNPNIVKLLDVYLVFEFLH-QDLKKFMDAFCHSHRVLHRDLKPQNLLILADFGLA
Sequence structure:	EKIGEGTYGVVYKVALKKITAIREISLLKELNPNIVKLLDVYLVFEFLH_QDLKKFMDAFCHSHRVLHRDLKPQNLLILADFGLA

Ligand affinity
ChEMBL ID:	CHEMBL482967
Bioaffinities:	111 records for 94 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	3-phosphoinositide dependent protein kinase-1	6.3	6.3	6.3	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	6.3	6.3	6.3	pKi	1
Homo sapiens	BR serine/threonine-protein kinase 1	7.1	7.1	7.1	pKi	1
Homo sapiens	CaM kinase II alpha	5.3	5.3	5.3	pKi	1
Homo sapiens	CaM kinase II beta	5.3	5.3	5.3	pKi	1
Homo sapiens	CaM kinase II delta	6	6	6	pKi	1
Homo sapiens	CaM kinase II gamma	5.9	5.9	5.9	pKi	1
Homo sapiens	cAMP-dependent protein kinase alpha-catalytic subunit	5.8	5.8	5.8	pKi	1
Homo sapiens	Casein kinase I alpha	6.6	6.6	6.6	pKi	1
Homo sapiens	Casein kinase I delta	7.3	7.3	7.3	pKi	1
Homo sapiens	Casein kinase I gamma 1	5.7	5.7	5.7	pKi	1
Homo sapiens	Casein kinase I gamma 2	6.3	6.3	6.3	pKi	1
Homo sapiens	Casein kinase II alpha	6.9	6.9	6.9	pKi	1
Homo sapiens	Cell division cycle 7-related protein kinase	6.7	6.7	6.7	pKi	1
Homo sapiens	c-Jun N-terminal kinase 1	7.1	7.1	7.1	pKi	1
Homo sapiens	c-Jun N-terminal kinase 2	7.1	7.1	7.1	pKi	1
Homo sapiens	Cyclin-dependent kinase 1	6.4	6.4	6.4	pKi	1
Homo sapiens	Cyclin-dependent kinase 2	6.4	6.4	7	pKi	2
Homo sapiens	Cyclin-dependent kinase 4	6	6	6	pKi	1
Homo sapiens	Cyclin-dependent kinase 5	6.7	6.7	6.7	pKi	1
Homo sapiens	Cyclin-dependent kinase 9	6.3	6.3	6.3	pKi	1
Homo sapiens	Death-associated protein kinase 3	6.9	6.9	6.9	pKi	1
Homo sapiens	Dual specificity protein kinase CLK2	6.3	6.3	6.3	pKi	1
Homo sapiens	Dual specificity protein kinase CLK4	7.1	7.1	7.1	pKi	1
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	6.6	6.6	6.6	pKi	1
Homo sapiens	Ephrin type-A receptor 2	6.6	6.6	6.6	pKi	1
Homo sapiens	Epidermal growth factor receptor erbB1	6	6	6	pKi	1
Homo sapiens	Fibroblast growth factor receptor 1	6.6	6.6	6.6	pKi	1
Homo sapiens	Fibroblast growth factor receptor 3	6.9	6.9	6.9	pKi	1
Homo sapiens	Glycogen synthase kinase-3 alpha	5.9	5.9	5.9	pKi	1
Homo sapiens	Glycogen synthase kinase-3 beta	5.8	5.8	5.8	pKi	1
Homo sapiens	Hepatocyte growth factor receptor	5.7	5.7	5.7	pKi	1
Homo sapiens	Homeodomain-interacting protein kinase 2	7.2	7.2	7.2	pKi	1
Homo sapiens	Homeodomain-interacting protein kinase 4	6.7	6.7	6.7	pKi	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	6.5	6.5	6.5	pKi	1
Homo sapiens	Insulin receptor	5.9	5.9	5.9	pKi	1
Homo sapiens	Interleukin-1 receptor-associated kinase 1	7.1	7.1	7.1	pKi	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	6.4	6.4	6.4	pKi	1
Homo sapiens	Leukocyte tyrosine kinase receptor	6.4	6.4	6.4	pKi	1
Homo sapiens	Macrophage colony stimulating factor receptor	6.2	6.2	6.2	pKi	1
Homo sapiens	MAP kinase p38 gamma	5.3	5.3	5.3	pKi	1
Homo sapiens	MAP kinase signal-integrating kinase 2	6.7	6.7	6.7	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	6	6	6	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	6.6	6.6	6.6	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	5.7	5.7	5.7	pKi	1
Homo sapiens	Mixed lineage kinase 7	5.7	5.7	5.7	pKi	1
Homo sapiens	NT-3 growth factor receptor	6.3	6.3	6.3	pKi	1
Homo sapiens	Phosphorylase kinase gamma subunit 2	6.4	6.4	6.4	pKi	1
Homo sapiens	Platelet-derived growth factor receptor alpha	7	7	7	pKi	1
Homo sapiens	Protein kinase C nu	7	7	7	pKi	1
Homo sapiens	Protein kinase N2	5.8	5.8	5.8	pKi	1
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	6.9	6.9	6.9	pKi	1
Homo sapiens	Rho-associated protein kinase 1	6.3	6.3	6.3	pKi	1
Homo sapiens	Rho-associated protein kinase 2	7	7	7	pKi	1
Homo sapiens	Ribosomal protein S6 kinase 1	5.4	5.4	6.3	pKi	2
Homo sapiens	Ribosomal protein S6 kinase alpha 3	5.7	5.7	5.7	pKi	2
Homo sapiens	Serine/threonine-protein kinase 17A	7.3	7.3	7.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase 2	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase AKT	5.1	5.1	5.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	7.4	7.4	7.4	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	7.5	7.5	8.1	pKi	2
Homo sapiens	Serine/threonine-protein kinase Aurora-B	7.7	7.7	7.7	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	8	8	8.6	pKi	2
Homo sapiens	Serine/threonine-protein kinase Aurora-C	7.2	7.2	7.2	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Chk1	6	6	6	pKi	1
Homo sapiens	Serine/threonine-protein kinase Chk2	5.8	5.8	5.8	pKi	1
Homo sapiens	Serine/threonine-protein kinase c-TAK1	7.3	7.3	7.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase D2	6.5	6.5	6.5	pKi	1
Homo sapiens	Serine/threonine-protein kinase MST2	6.1	6.1	6.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase NEK2	6.1	6.1	6.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase Nek4	6.4	6.4	6.4	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK 4	5.9	5.9	5.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase PLK4	7.6	7.6	7.6	pKi	1
Homo sapiens	Serine/threonine-protein kinase Sgk2	6.6	6.6	6.6	pKi	1
Homo sapiens	Serine/threonine-protein kinase TAO1	5.7	5.7	5.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase TBK1	7.2	7.2	7.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase WEE1	6.3	6.3	6.3	pKi	1
Homo sapiens	Stem cell growth factor receptor	6.4	6.4	6.4	pKi	1
Homo sapiens	Tyrosine kinase non-receptor protein 2	6.8	6.8	6.8	pKi	1
Homo sapiens	Tyrosine-protein kinase ABL	6.2	6.2	6.2	pKi	1
Homo sapiens	Tyrosine-protein kinase BLK	6.3	6.3	6.3	pKi	1
Homo sapiens	Tyrosine-protein kinase FER	6.3	6.3	6.3	pKi	1
Homo sapiens	Tyrosine-protein kinase FRK	6.8	6.8	6.8	pKi	1
Homo sapiens	Tyrosine-protein kinase FYN	6.6	6.6	6.6	pKi	1
Homo sapiens	Tyrosine-protein kinase ITK/TSK	6	6	6	pKi	1
Homo sapiens	Tyrosine-protein kinase JAK2	7.2	7.2	7.2	pKi	2
Homo sapiens	Tyrosine-protein kinase JAK3	6.2	6.2	6.2	pKi	2
Homo sapiens	Tyrosine-protein kinase LCK	5.6	5.6	6.2	pKi	2
Homo sapiens	Tyrosine-protein kinase Lyn	6.6	6.6	6.6	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	7.1	7.1	7.6	pIC50	2
Homo sapiens	Tyrosine-protein kinase receptor FLT3	7.4	7.4	8	pKi	2
Homo sapiens	Tyrosine-protein kinase receptor RET	6.9	6.9	6.9	pKi	1
Homo sapiens	Tyrosine-protein kinase SRC	6.1	6.1	6.5	pKi	2
Homo sapiens	Tyrosine-protein kinase SYK	6.4	6.4	6.4	pKi	1
Homo sapiens	Tyrosine-protein kinase TYK2	7.1	7.1	7.1	pKi	2
Homo sapiens	Vascular endothelial growth factor receptor 1	7	7	7	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 2	7.2	7.2	7.2	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 2	6.7	6.7	7.4	pKi	2

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 E
8

2 K
9

3 I
10

4 G
11

5 E
12

6 G
13

7 T
14

8 Y
15

9 G
16

10 V
17

11 V
18

12 Y
19

13 K
20

14 V
30

15 A
31

16 L
32

17 K
33

18 K
34

19 I
35

20 T
47

•

••

αC

b.l

21 A
48

22 I
49

23 R
50

24 E
51

25 I
52

26 S
53

27 L
54

28 L
55

29 K
56

30 E
57

31 L
58

32 N
59

33 P
61

34 N
62

35 I
63

36 V
64

37 K
65

38 L
66

39 L
67

40 D
68

•

hinge

linker

αD

αE

41 V
69

42 Y
77

43 L
78

44 V
79

45 F
80

46 E
81

47 F
82

48 L
83

49 H
84

50 _
_

51 Q
85

52 D
86

53 L
87

54 K
88

55 K
89

56 F
90

57 M
91

58 D
92

59 A
93

60 F
117

•

••

•

••

αE

c.l

VII

VIII

61 C
118

62 H
119

63 S
120

64 H
121

65 R
122

66 V
123

67 L
124

68 H
125

69 R
126

70 D
127

71 L
128

72 K
129

73 P
130

74 Q
131

75 N
132

76 L
133

77 L
134

78 I
135

79 L
143

80 A
144

•

DFG

a.l

81 D
145

82 F
146

83 G
147

84 L
148

85 A
149

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: