PDB-code
| Kinase structure | |
| Kinase: | MAPK12 (p38g) |
| Family: | MAPK |
| Group: | CMGC |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1501 |
| PDB: | 1CM8 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2000-05-17 |
| PubMed: | 10508788 |
| Chain: | A |
| Orthosteric ligand: | ANP |
 | |
| More entries for 1CM8 | |||
| 1CM8 | Chain: | B | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | - |
| G-rich loop rotation: | - |
| Quality Score: | 6.4 |
| Resolution: | 2.4 Å |
| Missing Residues: | 6 |
| Missing Atoms: | 12 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | FP-II | Cluster I4 | Ligand No | Protein No |
| Pocket alignment | |
| Uniprot sequence: | QPVGSGAYGAVCSVAIKKLRAYRELRLLKHMRENVIGLLDVYLVMPFMG-TDLGKLMKHYIHAAGIIHRDLKPGNLAVILDFGLA |
| Sequence structure: | QPV______AVCSVAIKKLRAYRELRLLKHMRENVIGLLDVYLVMPFMG_TDLGKLMKHYIHAAGIIHRDLKPGNLAVILDFGLA |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL1230989 |
| Bioaffinities: | No (p)Ki/(p)IC50/(p)EC50 values for kinases found (confidence ≥ 8). |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 Q 31 | 2 P 32 | 3 V 33 | 4 _ _ | 5 _ _ | 6 _ _ | 7 _ _ | 8 _ _ | 9 _ _ | 10 A 40 | 11 V 41 | 12 C 42 | 13 S 43 | 14 V 53 | 15 A 54 | 16 I 55 | 17 K 56 | 18 K 57 | 19 L 58 | 20 R 70 |
| • | • | • | • | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 A 71 | 22 Y 72 | 23 R 73 | 24 E 74 | 25 L 75 | 26 R 76 | 27 L 77 | 28 L 78 | 29 K 79 | 30 H 80 | 31 M 81 | 32 R 82 | 33 E 84 | 34 N 85 | 35 V 86 | 36 I 87 | 37 G 88 | 38 L 89 | 39 L 90 | 40 D 91 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 92 | 42 Y 106 | 43 L 107 | 44 V 108 | 45 M 109 | 46 P 110 | 47 F 111 | 48 M 112 | 49 G 113 | 50 _ _ | 51 T 114 | 52 D 115 | 53 L 116 | 54 G 117 | 55 K 118 | 56 L 119 | 57 M 120 | 58 K 121 | 59 H 122 | 60 Y 143 |
| • | • | •• | •• | •• | |||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 I 144 | 62 H 145 | 63 A 146 | 64 A 147 | 65 G 148 | 66 I 149 | 67 I 150 | 68 H 151 | 69 R 152 | 70 D 153 | 71 L 154 | 72 K 155 | 73 P 156 | 74 G 157 | 75 N 158 | 76 L 159 | 77 A 160 | 78 V 161 | 79 I 169 | 80 L 170 |
| • | |||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 171 | 82 F 172 | 83 G 173 | 84 L 174 | 85 A 175 | |||||||||||||||
| • | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
