PDB-code
| Kinase structure | |
| Kinase: | MAPK12 (p38g) |
| Family: | MAPK |
| Group: | CMGC |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1501 |
| PDB: | 1CM8 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2000-05-17 |
| PubMed: | 10508788 |
| Chain: | B |
| Orthosteric ligand: | ANP |
 | |
| More entries for 1CM8 | |||
| 1CM8 | Chain: | A | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | - |
| G-rich loop rotation: | - |
| Quality Score: | 5.6 |
| Resolution: | 2.4 Å |
| Missing Residues: | 6 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | FP-II | Cluster I1 I4 I5 I7 | Ligand Yes No Yes Yes | Protein No No No No |
| Pocket alignment | |
| Uniprot sequence: | QPVGSGAYGAVCSVAIKKLRAYRELRLLKHMRENVIGLLDVYLVMPFMG-TDLGKLMKHYIHAAGIIHRDLKPGNLAVILDFGLA |
| Sequence structure: | QPV______AVCSVAIKKLRAYRELRLLKHMRENVIGLLDVYLVMPFMG_TDLGKLMKHYIHAAGIIHRDLKPGNLAVILDFGLA |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL1230989 |
| Bioaffinities: | No (p)Ki/(p)IC50/(p)EC50 values for kinases found (confidence ≥ 8). |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 Q 1031 | 2 P 1032 | 3 V 1033 | 4 _ _ | 5 _ _ | 6 _ _ | 7 _ _ | 8 _ _ | 9 _ _ | 10 A 1040 | 11 V 1041 | 12 C 1042 | 13 S 1043 | 14 V 1053 | 15 A 1054 | 16 I 1055 | 17 K 1056 | 18 K 1057 | 19 L 1058 | 20 R 1070 |
| • | • | • | • | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 A 1071 | 22 Y 1072 | 23 R 1073 | 24 E 1074 | 25 L 1075 | 26 R 1076 | 27 L 1077 | 28 L 1078 | 29 K 1079 | 30 H 1080 | 31 M 1081 | 32 R 1082 | 33 E 1084 | 34 N 1085 | 35 V 1086 | 36 I 1087 | 37 G 1088 | 38 L 1089 | 39 L 1090 | 40 D 1091 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 1092 | 42 Y 1106 | 43 L 1107 | 44 V 1108 | 45 M 1109 | 46 P 1110 | 47 F 1111 | 48 M 1112 | 49 G 1113 | 50 _ _ | 51 T 1114 | 52 D 1115 | 53 L 1116 | 54 G 1117 | 55 K 1118 | 56 L 1119 | 57 M 1120 | 58 K 1121 | 59 H 1122 | 60 Y 1143 |
| • | • | •• | •• | •• | |||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 I 1144 | 62 H 1145 | 63 A 1146 | 64 A 1147 | 65 G 1148 | 66 I 1149 | 67 I 1150 | 68 H 1151 | 69 R 1152 | 70 D 1153 | 71 L 1154 | 72 K 1155 | 73 P 1156 | 74 G 1157 | 75 N 1158 | 76 L 1159 | 77 A 1160 | 78 V 1161 | 79 I 1169 | 80 L 1170 |
| • | |||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 1171 | 82 F 1172 | 83 G 1173 | 84 L 1174 | 85 A 1175 | |||||||||||||||
| • | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
