KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

V-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)

Kinase structure
Kinase:	Abl2 (ABL2)
Family:	Abl
Group:	TK
Species:	MOUSE
PDB:	4XLI
sc-PDB:
KIDFamMap:	Search
Release date:	2015-04-01
PubMed:	25849507
Chain:	A
Orthosteric ligand:	1N1

More entries for 4XLI
4XLI	Chain:	B

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	59.9° (18.7Å)
G-rich loop rotation:	38.9°
Quality Score:	8
Resolution:	2.5 Å
Missing Residues:	0
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets
front gate back	BP-I-A BP-I-B

Pocket alignment
Uniprot sequence:	HKLGGGQYGEVYVVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIVTEYMPYGNLLDYLREYLEKKNFIHRDLAARNCLVVADFGLS
Sequence structure:	HKLGGGQYGEVYVVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIVTEYMPYGNLLDYLREYLEKKNFIHRDLAARNCLVVADFGLS

Ligand affinity
ChEMBL ID:	CHEMBL1421
Bioaffinities:	404 records for 131 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	Activin receptor type-1	6.2	6.2	6.2	pKd	2
Homo sapiens	Activin receptor type-1	7.1	7.1	7.1	pKi	1
Homo sapiens	Activin receptor type-1B	6.5	6.5	6.5	pKd	2
Homo sapiens	Activin receptor type-2A	6.7	6.7	6.7	pKd	2
Homo sapiens	Activin receptor type-2B	6.2	6.2	6.2	pKd	2
Homo sapiens	Bone morphogenetic protein receptor type-1A	5.2	5.2	5.2	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-1B	7.3	7.3	7.3	pKd	1
Plasmodium falciparum (isolate 3D7)	Calcium-dependent protein kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	Casein kinase I epsilon	5.8	5.8	5.8	pKd	2
Homo sapiens	Chaperone activity of bc1 complex-like, mitochondrial	6.7	6.7	6.7	pKd	2
Homo sapiens	Discoidin domain-containing receptor 2	8.7	6.1	9.4	pIC50	5
Homo sapiens	Discoidin domain-containing receptor 2	8.5	7.8	8.5	pKd	4
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6	6	6	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6.2	6.2	6.2	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.9	5.9	5.9	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.8	5.8	5.8	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	8.5	8.5	8.5	pKd	1
Homo sapiens	Dual specificity testis-specific protein kinase 1	7.5	7.5	7.5	pKd	2
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 3	5.9	5.9	5.9	pKi	1
Homo sapiens	Ephrin type-A receptor 1	8.4	8.4	8.4	pKd	2
Homo sapiens	Ephrin type-A receptor 2	6.9	6.9	6.9	pIC50	1
Homo sapiens	Ephrin type-A receptor 2	9.1	9.1	9.1	pKd	2
Homo sapiens	Ephrin type-A receptor 2	8.4	8.4	8.4	pKi	1
Homo sapiens	Ephrin type-A receptor 3	10	10	10	pKd	2
Homo sapiens	Ephrin type-A receptor 4	8.9	8.9	8.9	pKd	2
Homo sapiens	Ephrin type-A receptor 5	9.6	9.6	9.6	pKd	2
Homo sapiens	Ephrin type-A receptor 6	5.7	5.7	5.7	pKd	1
Homo sapiens	Ephrin type-A receptor 8	9.6	9.6	9.6	pKd	2
Homo sapiens	Ephrin type-B receptor 1	9.4	9.4	9.4	pKd	2
Homo sapiens	Ephrin type-B receptor 2	8.4	8.4	8.4	pIC50	1
Homo sapiens	Ephrin type-B receptor 2	9.4	9.4	9.4	pKd	2
Homo sapiens	Ephrin type-B receptor 3	8.2	8.2	8.2	pKd	2
Homo sapiens	Ephrin type-B receptor 4	9.5	9.5	9.5	pKd	2
Homo sapiens	Epidermal growth factor receptor erbB1	6.8	5.5	7.7	pIC50	5
Homo sapiens	Epidermal growth factor receptor erbB1	6.9	5.6	7.1	pKd	22
Homo sapiens	Epithelial discoidin domain-containing receptor 1	8.3	8.3	9.3	pIC50	2
Homo sapiens	Epithelial discoidin domain-containing receptor 1	9.2	9.2	9.2	pKd	2
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	5.8	5.8	5.8	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	6.1	6.1	6.1	pIC50	1
Homo sapiens	Fibroblast growth factor receptor 1	5.4	5.4	5.4	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	5.7	5.7	5.7	pKi	1
Homo sapiens	Fibroblast growth factor receptor 2	5.9	5.9	5.9	pKd	2
Homo sapiens	Fibroblast growth factor receptor 3	5.4	5.4	5.4	pKd	1
Homo sapiens	Fibroblast growth factor receptor 3	5.9	5.9	5.9	pKi	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	5.3	5.3	5.3	pKi	1
Homo sapiens	LIM domain kinase 1	6.9	6.9	6.9	pIC50	1
Homo sapiens	LIM domain kinase 1	6.2	6.2	6.2	pKd	2
Homo sapiens	LIM domain kinase 1	6.6	6.6	6.6	pKi	1
Homo sapiens	LIM domain kinase 2	7.1	7.1	7.1	pKd	2
Homo sapiens	Macrophage colony stimulating factor receptor	8.1	8.1	8.3	pIC50	2
Homo sapiens	Macrophage colony stimulating factor receptor	9.2	9.2	9.2	pKd	2
Homo sapiens	MAP kinase p38 alpha	7.6	6.3	7.6	pKd	5
Homo sapiens	MAP kinase p38 alpha	7.5	7.5	7.5	pKi	1
Homo sapiens	MAP kinase p38 beta	6.4	6.4	6.4	pKd	2
Homo sapiens	Misshapen-like kinase 1	6.4	6.4	6.4	pKd	1
Homo sapiens	Misshapen-like kinase 1	6.1	6.1	6.1	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 10	5.6	5.6	5.6	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 13	5.3	5.3	5.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	6.9	6.9	6.9	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	6.6	6.6	6.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	6.5	6.5	6.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	5.4	5.4	5.4	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	6	6	6	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.9	5.9	5.9	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	6.2	6.2	6.2	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	5.5	5.5	5.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	7.4	7.4	7.4	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	7.8	7.8	7.8	pKi	1
Homo sapiens	Mixed lineage kinase 7	7.4	7.4	7.4	pKd	2
Homo sapiens	Mixed lineage kinase 7	7.3	7.3	7.3	pKi	1
Homo sapiens	myosin light chain kinase 2	5.5	5.5	5.5	pKd	1
Homo sapiens	Myotonin-protein kinase	5.9	5.9	5.9	pKd	2
Homo sapiens	Platelet-derived growth factor receptor alpha	7.2	7.2	8	pIC50	2
Homo sapiens	Platelet-derived growth factor receptor alpha	9.3	9.3	9.3	pKd	2
Homo sapiens	Platelet-derived growth factor receptor alpha	8	8	8	pKi	1
Homo sapiens	Platelet-derived growth factor receptor beta	7.6	7.6	7.6	pIC50	1
Homo sapiens	Platelet-derived growth factor receptor beta	9.2	9.2	9.2	pKd	2
Homo sapiens	Platelet-derived growth factor receptor beta	8.9	8.9	8.9	pKi	1
Homo sapiens	Protein kinase N2	5.3	5.3	5.3	pKi	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	6.2	6.2	6.2	pIC50	2
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	5.9	5.9	5.9	pKd	2
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	6.8	6.8	6.8	pKi	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	7.3	7.3	7.3	pKd	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	7.4	7.4	7.4	pKi	1
Homo sapiens	Receptor tyrosine-protein kinase erbB-3	7.8	7.8	7.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase 10	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase 2	6.1	6.1	6.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase 2	6.2	6.2	6.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase 25	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase 35	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase 36	6.7	6.7	6.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase Aurora-A	5.6	5.6	5.6	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	5	5	5	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	5.2	5.2	5.2	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	5.9	5.9	5.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase B-raf	6.2	6.2	6.3	pKd	4
Homo sapiens	Serine/threonine-protein kinase GAK	8.6	8.6	8.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase MRCK-A	5.7	5.7	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase MRCK-A	5.2	5.2	5.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase MRCK beta	5.7	5.7	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase MRCK gamma	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST1	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST4	5.7	5.7	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase mTOR	4.5	4.5	4.5	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Nek11	6.3	6.3	6.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase NEK2	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine protein kinase NLK	6.6	6.6	6.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase PLK4	5.7	5.7	5.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase RAF	6.8	6.8	6.8	pIC50	1
Homo sapiens	Serine/threonine-protein kinase RAF	6.2	6.2	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase receptor R3	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIPK2	7	7	7	pIC50	1
Homo sapiens	Serine/threonine-protein kinase RIPK2	7.5	7.5	7.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase SBK1	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK1	8.4	8.4	8.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK2	8.2	8.2	8.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK2	9.1	9.1	9.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase SIK3	7.6	7.6	7.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO1	6	6	6	pKi	1
Homo sapiens	Serine/threonine-protein kinase TAO2	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO3	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase TNNI3K	8	8	8	pKd	2
Homo sapiens	Serine/threonine-protein kinase ULK3	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase WEE1	5.2	5.2	5.2	pKd	3
Homo sapiens	SPS1/STE20-related protein kinase YSK4	7.1	7.1	7.1	pKd	1
Homo sapiens	Stem cell growth factor receptor	8.3	6.9	8.8	pIC50	9
Homo sapiens	Stem cell growth factor receptor	9.1	8.6	9.2	pKd	13
Homo sapiens	TGF-beta receptor type I	6.6	6.6	6.6	pKd	2
Homo sapiens	TGF-beta receptor type II	5.5	5.5	5.5	pKd	2
Homo sapiens	TRAF2- and NCK-interacting kinase	5.7	5.7	5.7	pKd	2
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	6.7	6.7	8.2	pIC50	2
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	6.9	6.8	6.9	pKd	3
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	7.1	7.1	9.3	pKi	2
Homo sapiens	Tyrosine kinase non-receptor protein 2	8.3	8.2	8.3	pKd	3
Homo sapiens	Tyrosine kinase non-receptor protein 2	8.6	8.6	8.6	pKi	1
Homo sapiens	Tyrosine-protein kinase ABL	8.5	5.8	9.8	pIC50	14
Homo sapiens	Tyrosine-protein kinase ABL	10.2	6.1	10.8	pKd	22
Homo sapiens	Tyrosine-protein kinase ABL2	9.8	9.8	9.8	pKd	2
Homo sapiens	Tyrosine-protein kinase BLK	9.7	9.7	9.7	pKd	2
Mus musculus	Tyrosine-protein kinase BLK	8.1	8.1	8.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase BMX	8.9	8.9	8.9	pKd	2
Homo sapiens	Tyrosine-protein kinase BRK	8.1	8.1	8.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase BRK	8.1	8.1	8.1	pKd	2
Homo sapiens	Tyrosine-protein kinase BRK	8.3	8.3	8.3	pKi	1
Homo sapiens	Tyrosine-protein kinase BTK	8.3	8.3	8.9	pIC50	3
Homo sapiens	Tyrosine-protein kinase BTK	8.9	8.9	8.9	pKd	2
Homo sapiens	Tyrosine-protein kinase CSK	9	9	9	pKd	2
Homo sapiens	Tyrosine-protein kinase FES	5.7	5.7	5.7	pKi	1
Homo sapiens	Tyrosine-protein kinase FGR	9.3	9.3	9.3	pKd	2
Homo sapiens	Tyrosine-protein kinase FRK	9.5	9.5	9.5	pKd	2
Homo sapiens	Tyrosine-protein kinase FYN	9.7	9.7	9.7	pIC50	1
Homo sapiens	Tyrosine-protein kinase FYN	9.1	9.1	9.1	pKd	2
Homo sapiens	Tyrosine-protein kinase HCK	9.5	9.5	9.5	pKd	2
Homo sapiens	Tyrosine-protein kinase HCK	9.5	9.5	9.5	pKi	1
Homo sapiens	Tyrosine-protein kinase ITK/TSK	6.6	6.6	6.6	pIC50	1
Homo sapiens	Tyrosine-protein kinase JAK2	6	6	6	pKd	4
Homo sapiens	Tyrosine-protein kinase JAK2	5.9	5.9	5.9	pKi	2
Homo sapiens	Tyrosine-protein kinase JAK3	6.2	6.2	6.2	pKd	2
Homo sapiens	Tyrosine-protein kinase LCK	8.5	8.4	9.4	pIC50	4
Homo sapiens	Tyrosine-protein kinase LCK	9.7	9.7	9.7	pKd	2
Mus musculus	Tyrosine-protein kinase LCK	10.2	10.2	10.2	pKi	1
Homo sapiens	Tyrosine-protein kinase Lyn	9.2	9.2	9.2	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor FLT3	5.2	5	5.5	pKd	7
Homo sapiens	Tyrosine-protein kinase receptor RET	5.7	5.7	6.4	pIC50	2
Homo sapiens	Tyrosine-protein kinase receptor RET	6.1	5.5	6.4	pKd	5
Homo sapiens	Tyrosine-protein kinase receptor UFO	5.7	5.7	5.7	pKi	1
Gallus gallus	Tyrosine-protein kinase SRC	6.3	6.3	9.4	pIC50	2
Gallus gallus	Tyrosine-protein kinase SRC	8	8	8	pKd	1
Homo sapiens	Tyrosine-protein kinase SRC	9.2	7.9	9.5	pIC50	9
Homo sapiens	Tyrosine-protein kinase SRC	9.7	8	9.7	pKd	4
Homo sapiens	Tyrosine-protein kinase Srms	7.9	7.9	7.9	pKd	2
Homo sapiens	Tyrosine-protein kinase Srms	9.2	9.2	9.2	pKi	1
Homo sapiens	Tyrosine-protein kinase SYK	5.5	5.5	5.5	pKd	2
Homo sapiens	Tyrosine-protein kinase SYK	6.7	6.7	6.7	pKi	1
Homo sapiens	Tyrosine-protein kinase TEC	6.5	6.5	6.5	pIC50	1
Homo sapiens	Tyrosine-protein kinase TEC	7.9	7.9	7.9	pKd	2
Homo sapiens	Tyrosine-protein kinase TXK	9.5	9.5	9.5	pIC50	1
Homo sapiens	Tyrosine-protein kinase TXK	8.7	8.7	8.7	pKd	2
Homo sapiens	Tyrosine-protein kinase TYK2	5.8	5.8	7	pKd	4
Homo sapiens	Tyrosine-protein kinase YES	9.3	9.3	9.3	pIC50	3
Homo sapiens	Tyrosine-protein kinase YES	9.5	9.5	9.5	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	5.3	5.3	5.3	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 2	5.6	5.6	5.6	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 2	5.5	5.5	5.5	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 2	5.9	5.9	5.9	pKi	1
Homo sapiens	Wee1-like protein kinase 2	6.3	6.3	6.7	pKd	2

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 H
292

2 K
293

3 L
294

4 G
295

5 G
296

6 G
297

7 Q
298

8 Y
299

9 G
300

10 E
301

11 V
302

12 Y
303

13 V
304

14 V
314

15 A
315

16 V
316

17 K
317

18 T
318

19 L
319

20 E
328

•

αC

b.l

21 F
329

22 L
330

23 K
331

24 E
332

25 A
333

26 A
334

27 V
335

28 M
336

29 K
337

30 E
338

31 I
339

32 K
340

33 P
342

34 N
343

35 L
344

36 V
345

37 Q
346

38 L
347

39 L
348

40 G
349

•

hinge

linker

αD

αE

41 V
350

42 Y
358

43 I
359

44 V
360

45 T
361

46 E
362

47 Y
363

48 M
364

49 P
365

50 Y
366

51 G
367

52 N
368

53 L
369

54 L
370

55 D
371

56 Y
372

57 L
373

58 R
374

59 E
375

60 Y
399

•

••

•••

•

αE

c.l

VII

VIII

61 L
400

62 E
401

63 K
402

64 K
403

65 N
404

66 F
405

67 I
406

68 H
407

69 R
408

70 D
409

71 L
410

72 A
411

73 A
412

74 R
413

75 N
414

76 C
415

77 L
416

78 V
417

79 V
425

80 A
426

•

DFG

a.l

81 D
427

82 F
428

83 G
429

84 L
430

85 S
431

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: