PDB-code
| Kinase structure | |
| Kinase: | Tyro3 (TYRO3) |
| Family: | Axl |
| Group: | TK |
| Species: | MOUSE |
| PDB: | 3QUP |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2011-12-21 |
| PubMed: | 22119469 |
| Chain: | A |
| Orthosteric ligand: | LUN |
 | |
| Structural information | |
| DFG conformation: | out-like |
| αC-helix conformation: | out |
| G-rich loop angle (distance): | 53° (16.6Å) |
| G-rich loop rotation: | 38° |
| Quality Score: | 7.6 |
| Resolution: | 1.9 Å |
| Missing Residues: | 1 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | Cluster I1 I4 I5 | Ligand No No No | Protein Yes Yes Yes | |
| Pocket alignment | |
| Uniprot sequence: | RMLGKGEFGSVREVAVKMLEFLREAACMKEFDPHVAKLVGVMVILPFMKHGDLHAFLLAYLSSRNFIHRDLAARNCMLVADFGLS |
| Sequence structure: | RMLGKGEFGSVREVAVKMLEFLREAACMKEFDPHVAKLVGVMVILPFMKHGDLHAFLLAYLSSRNFIHRDLAARNCMLVADFGL_ |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 R 512 | 2 M 513 | 3 L 514 | 4 G 515 | 5 K 516 | 6 G 517 | 7 E 518 | 8 F 519 | 9 G 520 | 10 S 521 | 11 V 522 | 12 R 523 | 13 E 524 | 14 V 537 | 15 A 538 | 16 V 539 | 17 K 540 | 18 M 541 | 19 L 542 | 20 E 554 |
| • | • | • | • | • | |||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 F 555 | 22 L 556 | 23 R 557 | 24 E 558 | 25 A 559 | 26 A 560 | 27 C 561 | 28 M 562 | 29 K 563 | 30 E 564 | 31 F 565 | 32 D 566 | 33 P 568 | 34 H 569 | 35 V 570 | 36 A 571 | 37 K 572 | 38 L 573 | 39 V 574 | 40 G 575 |
| • | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 576 | 42 M 590 | 43 V 591 | 44 I 592 | 45 L 593 | 46 P 594 | 47 F 595 | 48 M 596 | 49 K 597 | 50 H 598 | 51 G 599 | 52 D 600 | 53 L 601 | 54 H 602 | 55 A 603 | 56 F 604 | 57 L 605 | 58 L 606 | 59 A 607 | 60 Y 635 |
| • | • | •• | ••• | • | • | • | |||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 636 | 62 S 637 | 63 S 638 | 64 R 639 | 65 N 640 | 66 F 641 | 67 I 642 | 68 H 643 | 69 R 644 | 70 D 645 | 71 L 646 | 72 A 647 | 73 A 648 | 74 R 649 | 75 N 650 | 76 C 651 | 77 M 652 | 78 L 653 | 79 V 661 | 80 A 662 |
| •• | • | • | |||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 663 | 82 F 664 | 83 G 665 | 84 L 666 | 85 _ _ | |||||||||||||||
| ••• | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
