Version: 3.2
Updated: 29-Oct-2025
Protein kinase, cAMP dependent, catalytic, alpha
Kinase structure
Kinase:Prkaca (PKACa)
Family:PKA
Group:AGC
Species:MOUSE
PDB:1SYK
sc-PDB:
KIDFamMap:Search
Release date:2005-05-17
PubMed: 16253959
Chain:B
Click to open a 3D viewer
The orthosteric binding pocket


More entries for 1SYK
1SYKChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):67.3° (21.9Å)
G-rich loop rotation:49.6°
Quality Score:9.4
Resolution:2.8 Å
Missing Residues:0
Missing Atoms:6
Ligand binding mode
Waters
Cluster
I10
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA
Sequence structure:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA