Version: 3.2
Updated: 29-Oct-2025
Protein kinase, cAMP dependent, catalytic, alpha
Kinase structure
Kinase:Prkaca (PKACa)
Family:PKA
Group:AGC
Species:MOUSE
PDB:4O22
sc-PDB:
KIDFamMap:Search
Release date:2014-05-28
PubMed: 24786636
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 4O22
4O22Alternative model: AChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):57.4° (17.7Å)
G-rich loop rotation:60.8°
Quality Score:9.5
Resolution:1.7 Å
Missing Residues:0
Missing Atoms:5
Ligand binding mode
Waters
Cluster
I1
I3
I4
I5
I6
I8
I9
Ligand
No
No
No
No
No
No
No
Protein
Yes
No
Yes
Yes
No
Yes
No

Pocket alignment
Uniprot sequence:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA
Sequence structure:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA