Epidermal growth factor receptor
Kinase structure
Kinase:EGFR
Family:EGFR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1797
PDB:5CZI
sc-PDB:
KIDFamMap:Search
Release date:2015-09-30
PubMed: 26551075
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):71.7° (21.8Å)
G-rich loop rotation:38.9°
Quality Score:8
Resolution:2.6 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLITQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA
Sequence structure:KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLITQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGRA