Fms related tyrosine kinase 3
Kinase structure
Kinase:FLT3
Family:PDGFR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1807
PDB:1RJB
sc-PDB:
KIDFamMap:Search
Release date:2004-02-03
PubMed: 14759363
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:out
αC-helix conformation:in
G-rich loop angle (distance):61.9° (19.1Å)
G-rich loop rotation:44.5°
Quality Score:7.2
Resolution:2.1 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I6
I9
Ligand
No
No
No
Protein
Yes
No
Yes

Pocket alignment
Uniprot sequence:KVLGSGAFGKVMNVAVKMLALMSELKMMTQLGENIVNLLGAYLIFEYCCYGDLLNYLRSFLEFKSCVHRDLAARNVLVICDFGLA
Sequence structure:KVLGSGAFGKVMNVAVKMLALMSELKMMTQLGENIVNLLGAYLIFEYCCYGDLLNYLRSFLEFKSCVHRDLAARNVLVICDFGLA